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一种浆果多酚组分对……致病特性的影响 。 你提供的原文似乎不完整，“of”后面缺少具体内容。

Effects of a Berry Polyphenolic Fraction on the Pathogenic Properties of .

作者信息

Vaillancourt Katy, Ben Lagha Amel, Grenier Daniel

机构信息

Oral Ecology Research Group, Faculty of Dentistry, Université Laval, Quebec City, QC, Canada.

出版信息

Front Oral Health. 2022 Jun 16;3:923663. doi: 10.3389/froh.2022.923663. eCollection 2022.

DOI:10.3389/froh.2022.923663
PMID:35784661
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9245044/
Abstract

expresses a broad array of virulence factors that enable it to play a central role in the etiopathogenesis of periodontitis. The objective of the present study was to assess the effects of a berry polyphenolic fraction (Orophenol®) composed of extracts from cranberry, wild blueberry, and strawberry on the main pathogenic determinants of . Orophenol® attenuated the growth of and decreased its hemolytic activity, its adherence to a basement membrane matrix model, and its proteinase activities. The berry polyphenolic fraction also impaired the production of reactive oxygen species (ROS) by oral keratinocytes stimulated with . Lastly, using an model of oral keratinocyte barrier, the fraction exerted a protective effect against the damages mediated by . In conclusion, the berry polyphenolic fraction investigated in the present study attenuated several pathogenic properties of . Although future clinical investigations are required, our study provided evidence that the polyphenols contained in this fraction may represent bioactive molecules of high interest for the prevention and/or treatment of periodontal disease.

摘要

表达了多种毒力因子，使其能够在牙周炎的病因发病机制中发挥核心作用。本研究的目的是评估一种由蔓越莓、野生蓝莓和草莓提取物组成的浆果多酚组分（Orophenol®）对……主要致病决定因素的影响。Orophenol®减弱了……的生长，降低了其溶血活性、对基底膜基质模型的黏附以及其蛋白酶活性。该浆果多酚组分还损害了由……刺激的口腔角质形成细胞产生的活性氧（ROS）。最后，使用口腔角质形成细胞屏障的……模型，该组分对由……介导的损伤发挥了保护作用。总之，本研究中所研究的浆果多酚组分减弱了……的几种致病特性。尽管需要未来的临床研究，但我们的研究提供了证据，表明该组分中含有的多酚可能是对预防和/或治疗牙周疾病具有高度兴趣的生物活性分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/a301622a54b0/froh-03-923663-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/52f6e07d12e7/froh-03-923663-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/795471217799/froh-03-923663-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/6e91360b12c3/froh-03-923663-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/e59a8eb39d2e/froh-03-923663-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/1d3770bf4eea/froh-03-923663-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/4302b184b2d6/froh-03-923663-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/f069b61c17ed/froh-03-923663-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/a301622a54b0/froh-03-923663-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/52f6e07d12e7/froh-03-923663-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/795471217799/froh-03-923663-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/6e91360b12c3/froh-03-923663-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/e59a8eb39d2e/froh-03-923663-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/1d3770bf4eea/froh-03-923663-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/4302b184b2d6/froh-03-923663-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/f069b61c17ed/froh-03-923663-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ef9/9245044/a301622a54b0/froh-03-923663-g0008.jpg

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本文引用的文献

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Current Concepts in the Management of Periodontitis.牙周炎治疗的现状。
Int Dent J. 2021 Dec;71(6):462-476. doi: 10.1111/idj.12630. Epub 2021 Feb 19.
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Oral Infections and Systemic Health - More than Just Links to Cardiovascular Diseases.
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Nutrients. 2023 Oct 16;15(20):4384. doi: 10.3390/nu15204384.
口腔感染与全身健康——与心血管疾病的关联不止于此。
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J Food Biochem. 2021 Oct;45(10):e13910. doi: 10.1111/jfbc.13910. Epub 2021 Aug 23.
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An Overview of Physical, Microbiological and Immune Barriers of Oral Mucosa.口腔黏膜的物理、微生物和免疫屏障概述。
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