Majzoub J A, Carrazana E J, Shulman J S, Baker K J, Emanuel R L
Am J Physiol. 1987 May;252(5 Pt 1):E637-42. doi: 10.1152/ajpendo.1987.252.5.E637.
The Brattleboro rat has severe diabetes insipidus due to an autosomal recessive trait resulting in the inability to synthesize detectable amounts of hypothalamic vasopressin. To determine whether this abnormality is due to a regulatory defect in the Brattleboro rat's vasopressin gene, we studied changes in the hypothalamic content of vasopressin mRNA in normal Long-Evans and homozygous Brattleboro rats subjected to osmotic stress and correlated these changes with systemic responses to water deprivation. We report that the Brattleboro rat does have a marked defect in the regulation of vasopressin gene expression consisting of an inability to increase hypothalamic vasopressin mRNA content in response to severe osmotic stress.
布拉特洛维大鼠患有严重的尿崩症，这是由一种常染色体隐性性状导致的，使其无法合成可检测量的下丘脑抗利尿激素。为了确定这种异常是否是由于布拉特洛维大鼠抗利尿激素基因的调节缺陷所致，我们研究了正常长 Evans 大鼠和纯合布拉特洛维大鼠在受到渗透压应激时下丘脑抗利尿激素 mRNA 含量的变化，并将这些变化与对禁水的全身反应进行了关联。我们报告称，布拉特洛维大鼠在抗利尿激素基因表达调节方面确实存在明显缺陷，表现为在严重渗透压应激下无法增加下丘脑抗利尿激素 mRNA 的含量。
