Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, 518107, China.
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, 518107, China.
Biochem Biophys Res Commun. 2022 Sep 10;620:143-149. doi: 10.1016/j.bbrc.2022.06.088. Epub 2022 Jun 28.
Serotonin (5-hydroxytryptamine, 5-HT) and its receptors play important roles in the development and progression of malignant tumors. The effect of the 5-HT receptor 1D (HTR1D), a member of the serotonin receptor family, on gastric cancer (GC) is not clear. Analysis of clinical data has shown that high expression of HTR1D was associated with poor prognosis in patients with GC and was an independent risk factor for reduced overall survival (OS) and disease-free survival (DFS). The present study assessed the effects of HTR1D knockdown and the HTR1D inhibitor GR127935 on the biological behavior of GC cells, which both impaired the proliferation and migration of GC cells. RNA sequencing showed that GR127935 inhibited tumor progression by limiting DNA replication and the cell cycle, inducing ferroptosis, and affecting tumor metabolism. Taken together, these findings showed that HTR1D has a potent oncogenic effect on GC and may provide a novel therapeutic target.
血清素（5-羟色胺，5-HT）及其受体在恶性肿瘤的发生和发展中起着重要作用。5-羟色胺受体 1D（HTR1D）作为血清素受体家族的一员，其对胃癌（GC）的影响尚不清楚。临床数据分析表明，HTR1D 高表达与 GC 患者预后不良相关，是总生存（OS）和无病生存（DFS）降低的独立危险因素。本研究评估了 HTR1D 敲低和 HTR1D 抑制剂 GR127935 对 GC 细胞生物学行为的影响，这两种方法均能损害 GC 细胞的增殖和迁移。RNA 测序表明，GR127935 通过限制 DNA 复制和细胞周期、诱导铁死亡以及影响肿瘤代谢来抑制肿瘤进展。综上所述，这些发现表明 HTR1D 对 GC 具有很强的致癌作用，可能为其提供新的治疗靶点。
Zotero 插件