Deng Handan, Fan Xingli
Institute of Basic Medicine and Forensic Medicine, Hangzhou Medical College, Hangzhou 311399, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2022 Jun 25;38(6):2105-2119. doi: 10.13345/j.cjb.210711.
The intestinal microbiota is a complex micro-ecological system symbiotic with human body, which has attracted increasing attention in recent years. The intestinal microbiota plays important roles not only in maintaining normal physiological functions of the human body but also in the occurrence, development, diagnosis and treatment of tumors. This review summarized the relationship between the intestinal microbiota and tumor, highlighting the mechanisms by which intestinal microbiota modulates tumor occurrence, development and immunotherapy, particularly the immune checkpoint therapy. This review also summarized the currently available methods for enhancing the efficacy of tumor therapy through regulation of intestinal microbiota. Challenges in the field as well as future perspectives were also discussed.
肠道微生物群是与人体共生的复杂微生态系统，近年来受到越来越多的关注。肠道微生物群不仅在维持人体正常生理功能方面发挥重要作用，而且在肿瘤的发生、发展、诊断和治疗中也发挥着重要作用。本文综述了肠道微生物群与肿瘤之间的关系，重点阐述了肠道微生物群调节肿瘤发生、发展及免疫治疗尤其是免疫检查点治疗的机制。本文还总结了目前通过调节肠道微生物群提高肿瘤治疗疗效的可用方法。同时也讨论了该领域的挑战以及未来展望。
