State Key Laboratory of Military Stomatology & National, Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry & School of Stomatology, The Fourth Military Medical University, Xi' an, China.
Sannie Bioengineering Technology Co., Ltd., Tianjin, China.
J Appl Biomater Funct Mater. 2022 Jan-Dec;20:22808000221105727. doi: 10.1177/22808000221105727.
Both collagen fibres and nanohydroxyapatite crystals have anisotropic magnetisation, which allows them to be oriented by a high magnetic field. Highly oriented nanohydroxyapatite/collagen composites were prepared using a high magnetic field combined with in situ synthesis. These highly oriented composites were investigated and compared with conventional composites. The results showed that the collagen fibres in the magnetically induced highly oriented nanohydroxyapatite/collagen composites had a preferred orientation and smaller molecular spacing, while the nanohydroxyapatite crystals were tightly adhered along the collagen fibre surface. The magnetically induced composites exhibited superior resistance to swelling and degradation along with high compressive strength. This artificial composite, with a structure and composition similar to natural bone, represents a new idea for improving materials for vertical or horizontal bone augmentation.
胶原纤维和纳米羟基磷灰石晶体都具有各向异性的磁化特性，这使得它们可以通过强磁场进行定向排列。采用强磁场结合原位合成的方法制备了具有各向异性的纳米羟基磷灰石/胶原复合材料。对这些具有各向异性的复合材料进行了研究，并与传统复合材料进行了比较。结果表明，在磁场诱导下，纳米羟基磷灰石/胶原复合材料中的胶原纤维具有择优取向和较小的分子间距，而纳米羟基磷灰石晶体则紧密地附着在胶原纤维表面。磁诱导复合材料具有优异的抗溶胀和降解性能以及较高的抗压强度。这种具有类似于天然骨结构和组成的人工复合材料为改善垂直或水平骨增强材料提供了新的思路。
