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接种 SARS-CoV-2 奥密克戎 BA.1（B.1.1.529）变异株后叙利亚金黄地鼠的肺部病变。

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters.

机构信息

Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.

出版信息

Emerg Microbes Infect. 2022 Dec;11(1):1778-1786. doi: 10.1080/22221751.2022.2095932.

DOI:10.1080/22221751.2022.2095932
PMID:35787236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9295819/
Abstract

The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant.

摘要

奥密克戎 BA.1（B.1.1.529）SARS-CoV-2 变体的病毒基因组中存在大量突变，与免疫逃逸和病毒传播增加有关。目前尚不清楚人类感染奥密克戎 BA.1 后观察到的 COVID-19 疾病进展较轻微是由于病毒的致病性降低，还是由于疫苗接种或先前感染产生的预先存在的免疫力。在这里，我们用奥密克戎 BA.1 对仓鼠进行接种，以评估与德尔塔（B.1.617.2）相比，其致病性和病毒脱落动力学，以及与先前 SARS-CoV-2 614G 感染后再次用奥密克戎 BA.1 进行重挑战的动物。与感染德尔塔的动物相比，感染奥密克戎 BA.1 的动物的临床症状、病理变化和病毒脱落减少，但仍显示出肺炎的大体和组织病理学证据。预先存在的免疫力减少了病毒脱落并防止了肺炎。我们的数据表明，观察到的疾病严重程度降低部分是由于奥密克戎 BA.1 变体的固有特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/e4e64a0bda5e/TEMI_A_2095932_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/3f0339853e93/TEMI_A_2095932_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/26d5f3e5f194/TEMI_A_2095932_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/adf18223133d/TEMI_A_2095932_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/e4e64a0bda5e/TEMI_A_2095932_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/3f0339853e93/TEMI_A_2095932_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/26d5f3e5f194/TEMI_A_2095932_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/adf18223133d/TEMI_A_2095932_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2036/9295819/e4e64a0bda5e/TEMI_A_2095932_F0004_OC.jpg

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The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads.德尔塔变异株被奥密克戎取代：对住院和上呼吸道病毒载量的调查。
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Booster vaccination with Ad26.COV2.S or an Omicron-adapted vaccine in pre-immune hamsters protects against Omicron BA.2.在未免疫的仓鼠中使用Ad26.COV2.S或奥密克戎适应疫苗进行加强免疫可预防奥密克戎BA.2。
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The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters.奥密克戎（B.1.1.529）关切变异株不易感染叙利亚仓鼠。
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An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies.一种传染性 SARS-CoV-2 B.1.1.529 奥密克戎病毒能够逃避治疗性单克隆抗体的中和作用。
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