Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Endocr Disord. 2022 Jul 4;22(1):171. doi: 10.1186/s12902-022-01088-2.
Diabetic nephropathy occurs in about one-third of diabetic patients. This health problem is characterized by increased urinary albumin excretion, leading to decreased glomerular filtration rate and renal failure. In this regard, previous investigations have revealed the possibility of a relationship between vitamin D deficiency and diabetic nephropathy. The present study assessed the relationship between vitamin D deficiency and albuminuria in patients with type 2 diabetes.
This study was conducted with 200 participants with type 2 diabetes mellitus from December 2019 to January 2021. The patients' 25-hydroxyvitamin D (25OHD) serum level and urinary albumin-to-creatinine ratio (UACR) were measured concurrently. Afterward, the subjects were divided into three groups based on their albuminuria level. Finally, 25OHD serum level and other clinical characteristics were compared among these albuminuria groups, and the relation between albuminuria level and 25OHD was analyzed.
The prevalence of vitamin D deficiency in macroalbuminuric patients (UACR≥300 mg/g) was 61.8%, and in microalbuminuric (30 ≤ UACR< 300 mg/g) and normoalbuminuric groups (UACR< 30 mg/g) was 33.3% and 24%, respectively. Further analysis revealed a significant negative relationship between 25OHD and albuminuria(r = - 0.257, p-value< 0.001). According to ROC curve analysis, a 25OHD level ≤ 21 ng/ml was considered an optimal cut-off point value for having macroalbuminuria in diabetic patients.
The current study evaluates the relation between vitamin D deficiency and the prevalence of albuminuria in the setting of diabetes. Overall, the prevalence of macroalbuminuria increased when the 25OHD serum level was less than 20 ng/ml.
大约三分之一的糖尿病患者会发生糖尿病肾病。这种健康问题的特征是尿白蛋白排泄增加，导致肾小球滤过率下降和肾衰竭。在这方面，先前的研究已经揭示了维生素 D 缺乏与糖尿病肾病之间可能存在的关系。本研究评估了 2 型糖尿病患者维生素 D 缺乏与白蛋白尿之间的关系。
本研究纳入了 2019 年 12 月至 2021 年 1 月期间的 200 名 2 型糖尿病患者。同时测量了患者的 25-羟维生素 D（25OHD）血清水平和尿白蛋白与肌酐比值（UACR）。然后，根据白蛋白尿水平将受试者分为三组。最后，比较了这些白蛋白尿组之间的 25OHD 血清水平和其他临床特征，并分析了白蛋白尿水平与 25OHD 的关系。
在大量白蛋白尿患者（UACR≥300 mg/g）中，维生素 D 缺乏的患病率为 61.8%，在微量白蛋白尿（30 ≤ UACR< 300 mg/g）和正常白蛋白尿组（UACR< 30 mg/g）中分别为 33.3%和 24%。进一步分析表明，25OHD 与白蛋白尿之间存在显著的负相关关系（r = - 0.257，p 值< 0.001）。根据 ROC 曲线分析，当 25OHD 水平≤21 ng/ml 时，被认为是糖尿病患者发生大量白蛋白尿的最佳截断点值。
本研究评估了维生素 D 缺乏与糖尿病患者白蛋白尿患病率之间的关系。总体而言，当 25OHD 血清水平低于 20 ng/ml 时，大量白蛋白尿的患病率增加。
