National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Chin Med J (Engl). 2022 May 20;135(10):1213-1222. doi: 10.1097/CM9.0000000000002158.
The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.
由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病大流行给全球带来了重大的公共卫生挑战。越来越多鉴定出的病毒谱系表明，SARS-CoV-2 基因组正在快速进化。病毒基因组突变可能导致抗原漂移或转变，这是 SARS-CoV-2 逃避人体免疫系统并改变其传染性和毒力的重要方式。在此，我们总结了 SARS-CoV-2 基因组中的功能突变，以描述其适应进化，为疫苗开发、治疗以及控制和干预措施提供信息。
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