Criner Gerard J, Agusti Alvar, Borghaei Hossein, Friedberg Joseph, Martinez Fernando J, Miyamoto Curtis, Vogelmeier Claus F, Celli Bartolome R
Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States.
Cátedra Salud Respiratoria, University of Barcelona; Respiratory Institute, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, , Centro de Investigacion Biomedica en Red Enfermedades Respiratorias, Barcelona, Spain.
Chronic Obstr Pulm Dis. 2022 Jul 29;9(3):454-476. doi: 10.15326/jcopdf.2022.0296.
Chronic obstructive pulmonary disease (COPD) and lung cancer are common global causes of morbidity and mortality. Because both diseases share several predisposing risks, the 2 diseases may occur concurrently in susceptible individuals. The diagnosis of COPD has important implications for the diagnostic approach and treatment options if lesions concerning for lung cancer are identified during screening. Importantly, the presence of COPD has significant implications on prognosis and management of patients with lung cancer. In this monograph, we review the mechanistic linkage between lung cancer and COPD, the impact of lung cancer screening on patients at risk, and the implications of the presence of COPD on the approach to the diagnosis and treatment of lung cancer. This manuscript succinctly reviews the epidemiology and common pathogenetic factors for the concurrence of COPD and lung cancer. Importantly for the clinician, it summarizes the indications, benefits, and complications of lung cancer screening in patients with COPD, and the assessment of risk factors for patients with COPD undergoing consideration of various treatment options for lung cancer.
慢性阻塞性肺疾病（COPD）和肺癌是全球发病率和死亡率的常见原因。由于这两种疾病有若干共同的易感风险，在易感个体中这两种疾病可能同时发生。如果在筛查期间发现了可疑肺癌病变，COPD的诊断对于诊断方法和治疗选择具有重要意义。重要的是，COPD的存在对肺癌患者的预后和管理有重大影响。在本专著中，我们回顾了肺癌与COPD之间的机制联系、肺癌筛查对高危患者的影响，以及COPD的存在对肺癌诊断和治疗方法的影响。本手稿简要回顾了COPD和肺癌并发的流行病学及常见致病因素。对临床医生来说重要的是，它总结了COPD患者肺癌筛查的适应症、益处和并发症，以及考虑肺癌各种治疗方案时COPD患者的危险因素评估。
