Emmerich Ilka Ute
Institut für Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinische Fakultät der Universität Leipzig.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2022 Jun;50(3):213-224. doi: 10.1055/a-1867-2855. Epub 2022 Jul 5.
In 2021, 8 novel pharmaceutical agents for small animals were released on the German market: The specific monoclonal antibodies bedinvetmab (Librela) and frunevetmab (Solensia), the cyclooxygenase-2 inhibitor enflioxib (Daxocox), the ectoparasitic esafoxolaner (NexGard Combo) of the isoxazoline group, the anti-haemorrhagic etamsylate (Hemosilate), the antidepressant mirtazapine (Mirataz), the alpha-selective sympathomimetic tetryzoline for ophthalmic use (Zolicep) and the cytostatic tigilanol tiglate (Stelfonta). No active substance received an animal species extension. In addition, for small animals, there were new releases of two agents in a novel pharmaceutical formulation (cefalexin, gentamicin), five drugs with a new content of the active ingredient (metronidazole, pimobendan, thiamazole, tramadol, trilostane), one veterinary drug with a new combination of active ingredients (lotilaner + milbemycin oxime), one drug with a new route of administration (propofol) and furthermore two temporarily non-available active ingredients for certain animal species were reapproved in new drugs (levothyroxine for cats and oxytetracycline for dogs and cats).
2021年，8种新型小动物用药物在德国市场上市：特异性单克隆抗体贝地维单抗（利倍乐）和氟鲁韦单抗（索兰西）、环氧化酶-2抑制剂恩氟昔布（达索昔）、异恶唑啉类外寄生虫防治药艾沙呋拉纳（尼可信组合装）、抗出血药酚磺乙胺（止血芳酸）、抗抑郁药米氮平（米氮佳）、眼科用α-选择性拟交感神经药四氢唑啉（佐利克）以及细胞生长抑制剂替吉兰醇替格列酸盐（斯泰尔丰塔）。没有活性物质获得动物种属扩展。此外，针对小动物，有两种药物以新剂型上市（头孢氨苄、庆大霉素），五种药物的活性成分含量有新变化（甲硝唑、匹莫苯丹、甲巯咪唑、曲马多、曲洛司坦），一种兽药的活性成分有新组合（洛替拉纳+米尔贝肟），一种药物有新的给药途径（丙泊酚），而且有两种某些动物种属暂时无法获得的活性成分在新药中重新获批（猫用左甲状腺素以及犬猫用土霉素）。
