白细胞介素-18 基因型对台湾地区人群肺癌发病风险的重要影响

Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese.

机构信息

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

出版信息

Anticancer Res. 2022 Jul;42(7):3381-3387. doi: 10.21873/anticanres.15825.

DOI:10.21873/anticanres.15825

PMID:35790262

Abstract

BACKGROUND/AIM: The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer.

MATERIALS AND METHODS

IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology.

RESULTS

The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137.

CONCLUSION

IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese.

摘要

背景/目的：肺癌患者白细胞介素-18（IL-18）的高表达引起了我们的兴趣，促使我们研究 IL-18 基因型在肺癌中的作用。

材料和方法

通过 PCR-RFLP 方法确定了 358 例肺癌病例和 716 例对照中 IL-18-656（rs1946519）、-607（rs1946518）和-137（rs187238）的基因型。

结果

IL-18-607 的基因型和等位基因频率分布在病例和对照组之间存在差异，但 -656 或-137 则没有。与对照组（51.4%和 24.7%）相比，肺癌患者的 IL-18-607AC 和 CC 基因型均较低（45.8%和 16.2%）。此外，IL-18-607AC 和 CC 基因型在不吸烟者和吸烟者中的比例均明显较低。另一方面，IL-18-656 或-137 则没有差异分布。