千金藤素抗新型冠状病毒2的抗病毒活性研究进展
[Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2].
作者信息
Fan H, Liu K, Hong B, He S, Han P, Li M, Wang S, Tong Y
机构信息
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2022 Jun 20;42(6):955-956. doi: 10.12122/j.issn.1673-4254.2022.06.22.
As a member of the dibenzyl isoquinoline alkaloid family, cepharathine is an alkaloid from the traditional Chinese medicine cepharathine, which is mainly used for treatment of leukopenia and other diseases. Recent studies of the inhibitory effect of cepharathine against SARS-CoV-2 have attracted widespread attention and aroused heated discussion. As the original discoverer of the anti-SARS-CoV-2 activity of cepharanthine, here we briefly summarize the discovery of cepharanthine and review important progress in relevant studies concerning the discovery and validation of anti-SARS-CoV-2 activity of cepharathine, its antiviral mechanisms and clinical trials of its applications in COVID-19 therapy.
千金藤素作为二苄基异喹啉生物碱家族的一员，是一种源自传统中药千金藤的生物碱，主要用于治疗白细胞减少症等疾病。千金藤素对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）抑制作用的最新研究引起了广泛关注并引发了热烈讨论。作为千金藤素抗SARS-CoV-2活性的最初发现者，在此我们简要总结千金藤素的发现过程，并回顾有关千金藤素抗SARS-CoV-2活性的发现与验证、其抗病毒机制以及在2019冠状病毒病（COVID-19）治疗中应用的临床试验等相关研究的重要进展。
Zotero 插件