Department of Food and Nutrition, Chonnam National University, 77 Yongbong-ro, Bukgu, Gwangju, 61186, South Korea.
Department of Orthopedic Surgery, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
Sci Rep. 2022 Jul 5;12(1):11372. doi: 10.1038/s41598-022-15025-9.
Most studies on osteoarthritis (OA) and vitamin D status were performed in Whites with relatively adequate vitamin D status. Associations may differ by baseline 25-hydroxyvitamin D (25(OH)D) and race. We assessed the odds of OA and joint pain according to vitamin D status in Korean adults ≥ 50 years of age in the nationally representative Korea National Health and Nutrition Examination Survey (n = 8575). Agreement between radiologic OA (ROA) and self-reported OA were also assessed. Multivariate logistic regression was performed and participants were stratified by sex. Adults with serum 25(OH)D < 12 ng/mL and 12 to < 20 ng/mL had 26% and 18% lower odds of knee ROA, respectively, compared to those with 25(OH)D ≥ 20 ng/mL. Similar results were observed in men, but not women. No associations were found between 25(OH)D and knee ROA severity, lumbar spine ROA, symptomatic OA, or knee pain. Sensitivity of self-reported OA was low (27%), indicating a weak possibility of reverse causation. Prospective studies are required to identify the possible causality of vitamin D on OA in Korean men.
大多数关于骨关节炎 (OA) 和维生素 D 状况的研究都是在维生素 D 状况相对充足的白种人群中进行的。关联可能因基线 25-羟维生素 D (25(OH)D) 和种族而有所不同。我们评估了维生素 D 状况与韩国≥50 岁成年人 OA 和关节痛之间的相关性，该研究基于全国代表性的韩国国家健康和营养检查调查 (n=8575)。还评估了放射学 OA (ROA) 和自我报告 OA 之间的一致性。进行了多变量逻辑回归，并按性别对参与者进行分层。与血清 25(OH)D≥20ng/mL 的成年人相比，血清 25(OH)D<12ng/mL 和 12-<20ng/mL 的成年人膝关节 ROA 的几率分别降低了 26%和 18%。在男性中观察到了类似的结果，但在女性中没有。在男性中，25(OH)D 与膝关节 ROA 严重程度、腰椎 ROA、有症状的 OA 或膝关节疼痛之间没有关联。自我报告 OA 的敏感性较低 (27%)，表明反向因果关系的可能性较小。需要前瞻性研究来确定维生素 D 对韩国男性 OA 的可能因果关系。
