MTA1：前列腺癌中的重要调节因子。

MTA1: A Vital Modulator in Prostate Cancer.

机构信息

Graduate School of Hebei Medical University, Shijiazhuang, China.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Curr Protein Pept Sci. 2022;23(7):456-464. doi: 10.2174/1389203723666220705152713.

DOI:10.2174/1389203723666220705152713

PMID:35792131

Abstract

Prostate cancer (PCa) is the most frequent cancer of the male genitourinary system and the second most common cancer in men worldwide. PCa has become one of the leading diseases endangering men's health in Asia in recent years, with a large increase in morbidity and mortality. MTA1 (metastasis-associated antigen-1), a transcriptional coregulator involved in histone deacetylation and nucleosome remodeling, is a member of the MTA family. MTA1 is involved in cell signaling, chromosomal remodeling, and transcriptional activities, all of which are important for epithelial cell progression, invasion, and growth. MTA1 has been demonstrated to play a significant role in the formation, progression, and metastasis of PCa, and MTA1 expression is specifically linked to PCa bone metastases. Therefore, MTA1 may be a potential target for PCa prevention and treatment. Here, we reviewed the structure, function, and expression of MTA1 in PCa as well as drugs that target MTA1 to highlight a potential new treatment for PCa.

摘要

前列腺癌（PCa）是男性泌尿生殖系统中最常见的癌症，也是全球男性中第二常见的癌症。近年来，PCa 已成为亚洲危害男性健康的主要疾病之一，发病率和死亡率均大幅上升。MTA1（转移相关抗原-1）是一种参与组蛋白去乙酰化和核小体重塑的转录共调节剂，是 MTA 家族的一员。MTA1 参与细胞信号转导、染色质重塑和转录活性，这些对于上皮细胞的进展、侵袭和生长都很重要。已经证明 MTA1 在 PCa 的形成、进展和转移中发挥重要作用，并且 MTA1 的表达与 PCa 骨转移特异性相关。因此，MTA1 可能是 PCa 预防和治疗的一个潜在靶点。在这里，我们综述了 MTA1 在 PCa 中的结构、功能和表达，以及针对 MTA1 的药物，以突出 PCa 的一种潜在新治疗方法。