Misiak Błażej, Kowalski Krzysztof, Stańczykiewicz Bartłomiej, Bartoli Francesco, Carrà Giuseppe, Samochowiec Jerzy, Samochowiec Agnieszka, Frydecka Dorota
Department of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, Poland.
Department of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, Poland.
Front Neuroendocrinol. 2022 Oct;67:101013. doi: 10.1016/j.yfrne.2022.101013. Epub 2022 Jul 2.
Impaired hormonal regulation of appetite may contribute to higher cardiovascular risk in bipolar disorder (BD). We performed a systematic review and meta-analysis of studies investigating peripheral blood levels of appetite-regulating hormones in BD and controls. A total of 32 studies were included. Leptin and insulin levels were significantly elevated in patients with BD during euthymia, but not in other mood states. Greater differences in the number of male participants between patients with BD and healthy controls were associated with higher effect size estimates for the levels of insulin. There were significant positive correlations of effect size estimates for the levels of adiponectin with the percentage of individuals with type I BD and duration of BD. Our findings point to the mechanisms underlying high rates of cardiometabolic comorbidities in BD. Moreover, they suggest that investigating hormonal regulation of appetite might help to understand differences in the neurobiology of BD types.
食欲的激素调节受损可能会增加双相情感障碍（BD）患者的心血管疾病风险。我们对研究BD患者和对照组外周血中食欲调节激素水平的研究进行了系统评价和荟萃分析。共纳入32项研究。在心境正常期，BD患者的瘦素和胰岛素水平显著升高，但在其他情绪状态下则不然。BD患者与健康对照组之间男性参与者数量的较大差异与胰岛素水平的效应大小估计值较高有关。脂联素水平的效应大小估计值与I型BD患者的百分比和BD病程呈显著正相关。我们的研究结果指出了BD患者中心血管代谢合并症高发的潜在机制。此外，研究结果还表明，探究食欲的激素调节可能有助于理解BD不同类型神经生物学的差异。
