Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK; School of Sport and Health Sciences, St. Luke's Campus, University of Exeter, Exeter, UK.
Institute for Clinical Exercise and Health Science, University of the West of Scotland, Blantyre, UK.
Nitric Oxide. 2022 Oct 1;127:1-9. doi: 10.1016/j.niox.2022.06.007. Epub 2022 Jul 2.
Nitric oxide is a key signalling molecule that elicits a range of biological functions to maintain vascular homeostasis. A reduced availability of nitric oxide is implicated in the progression of cardiovascular diseases and increases the risk of pathogenic events.
To compare the concentration of nitric oxide metabolites in healthy adults between winter and summer months.
An observational study of healthy adults (age 32 ± 9 years) living in central Scotland.
Thirty-four healthy adults (13 females) were monitored for 7 days in summer and winter to record sunlight exposure (ultraviolet-A (UV-A) radiation), diet, and physical activity. At the end of each phase, blood pressure was measured, and samples of blood and saliva collected. The samples were analysed to determine the concentrations of plasma and salivary nitrate and nitrite and serum 25-hydroxyvitamin D (25(OH)D).
The participants maintained similar diets in each measurement phase but were exposed to more UV-A radiation (550%) and undertook more moderate-vigorous physical activity (23%) in the summer than in winter. Plasma nitrite (46%) and serum 25(OH)D (59%) were higher and blood pressure was lower in the summer compared to winter months. Plasma nitrite concentration was negatively associated with systolic, diastolic, and mean arterial blood pressure.
Plasma nitrite, an established marker of nitric oxide synthesis, is higher in healthy adults during the summer than in winter. This may be mediated by a greater exposure to UV-A which stimulates the release of nitric oxide metabolites from skin stores. While it is possible that seasonal variation in nitric oxide availability may contribute to an increased blood pressure in the winter months, the overall impact on cardiovascular health remains to be determined.
一氧化氮是一种关键的信号分子，它引发了一系列生物学功能，以维持血管内环境的稳定。一氧化氮的供应减少与心血管疾病的进展有关，并增加了致病事件的风险。
比较健康成年人在冬夏两季血液中一氧化氮代谢物的浓度。
这是一项在苏格兰中部居住的健康成年人（年龄 32±9 岁）中进行的观察性研究。
34 名健康成年人（13 名女性）在夏季和冬季各监测 7 天，记录阳光暴露（紫外线-A（UVA）辐射）、饮食和身体活动情况。在每个阶段结束时，测量血压，并采集血液和唾液样本。分析样本以确定血浆和唾液硝酸盐和亚硝酸盐以及血清 25-羟维生素 D（25(OH)D）的浓度。
参与者在每个测量阶段都保持相似的饮食，但在夏季比冬季暴露于更多的 UVA 辐射（550%），并进行了更多的中等至剧烈的身体活动（23%）。与冬季相比，夏季血浆中亚硝酸盐（46%）和血清 25(OH)D（59%）水平更高，血压更低。血浆中亚硝酸盐浓度与收缩压、舒张压和平均动脉血压呈负相关。
在健康成年人中，夏季血液中一氧化氮合成的既定标志物——血浆亚硝酸盐的浓度高于冬季。这可能是由于更多地暴露于 UVA 辐射，从而刺激皮肤储存的一氧化氮代谢物释放。虽然一氧化氮可用性的季节性变化可能导致冬季血压升高，但对心血管健康的总体影响仍需确定。
