Department of Ophthalmology, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Department of Pediatric Nephrology, University of Health Sciences, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Photodiagnosis Photodyn Ther. 2022 Sep;39:102990. doi: 10.1016/j.pdpdt.2022.102990. Epub 2022 Jul 2.
This study aimed to investigate the presence of subclinical inflammation in the eye by examining corneal and lens changes in children with familial Mediterranean fever (FMF) and provide the regulation for follow-up and treatment protocols according to the presence of signs of inflammation.
This is a cross-sectional, case-control study.
Topographic parameters and corneal and lens densitometry of 48 patients with FMF (10.12 ± 3.84 years [range: 5-19 years]) and 33 healthy volunteers (10.94 ± 3.78 years [range: 5-19 years]; p > 0.05) were evaluated with a Scheimpflug camera. For corneal densitometric measurements, the cornea was divided into four concentric radial zones and anterior, central, and posterior layers according to corneal thickness. The mean densitometry value for the crystalline lens was calculated in three zones around the center of the pupil.
Corneal light backscattering in all layers and zones of the cornea were similar between the patient and control groups. Lens densitometry values in the three zones did not differ between the two groups (p > 0.05). Maximum lens densitometry values were found to be significantly higher in the patient group (22.14 vs 19.11; p = 0.011).
Monitoring the cornea and lens density in patients with FMF using Pentacam may help to show the presence of subclinical inflammation and regulate the follow-up and treatment protocols. Larger sample sizes and prospective design studies are needed to reach more conclusive results.
本研究旨在通过检查家族性地中海热（FMF）患儿的角膜和晶状体变化，研究眼部亚临床炎症的存在，并根据炎症迹象的存在为随访和治疗方案提供规定。
这是一项横断面、病例对照研究。
使用 Scheimpflug 相机评估 48 名 FMF 患者（10.12±3.84 岁[范围：5-19 岁]）和 33 名健康志愿者（10.94±3.78 岁[范围：5-19 岁]）的角膜和晶状体密度的体视学参数。为了进行角膜密度测量，根据角膜厚度将角膜分为四个同心的放射状区域和前、中、后层。在瞳孔中心周围的三个区域计算晶状体的平均密度值。
两组患者的角膜各层和各区域的角膜光反向散射相似。两组之间三个区域的晶状体密度值没有差异（p>0.05）。患者组的最大晶状体密度值明显更高（22.14 与 19.11；p=0.011）。
使用 Pentacam 监测 FMF 患者的角膜和晶状体密度可能有助于显示亚临床炎症的存在，并调节随访和治疗方案。需要更大的样本量和前瞻性设计研究来得出更具结论性的结果。
