Leiden University Centre for Linguistics, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands; Institute of Cognitive Neuroscience, University College London, London, UK.
Leiden University Centre for Linguistics, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Neuroimage. 2022 Oct 1;259:119441. doi: 10.1016/j.neuroimage.2022.119441. Epub 2022 Jul 2.
The cytoarchitectonically tripartite organization of the inferior parietal cortex (IPC) into the rostral, the middle and the caudal clusters has been generally ignored when associating different functions to this part of the cortex, resulting in inconsistencies about how IPC is understood. In this study, we investigated the patterns of functional connectivity of the caudal IPC in a task requiring cognitive control, using multiband EPI. This part of the cortex demonstrated functional connectivity patterns dissimilar to a cognitive control area and at the same time the caudal IPC showed negative functional associations with both task-related brain areas and the precuneus cortex, which is active during resting state. We found evidence suggesting that the traditional categorization of different brain areas into either task-related or resting state-related networks cannot accommodate the functions of the caudal IPC. This underlies the hypothesis about a new brain functional category as a modulating cortical area proposing that its involvement in task performance, in a modulating manner, is marked by deactivation in the patterns of functional associations with parts of the brain that are recognized to be involved in doing a task, proportionate to task difficulty; however, its patterns of functional connectivity in some other respects do not correspond to the resting state-related parts of the cortex.
下顶叶皮层（IPC）的细胞构筑学三分组织，即额部、中部和尾部簇，在将不同功能与皮质的这一部分相关联时通常被忽略，导致人们对 IPC 的理解存在不一致。在这项研究中，我们使用多频带 EPI 研究了在需要认知控制的任务中尾部 IPC 的功能连接模式。这部分皮质表现出与认知控制区域不同的功能连接模式，同时尾部 IPC 与与任务相关的大脑区域和后扣带回皮质表现出负功能关联，后扣带回皮质在静息状态下活跃。我们发现的证据表明，将不同大脑区域传统地分为与任务相关或与静息状态相关的网络的分类法不能适应尾部 IPC 的功能。这为新的大脑功能类别提供了假设，即作为一个调节皮质区域，其参与任务表现的方式是与被认为参与任务的大脑部分的功能关联模式失活有关，与任务难度成比例；然而，其在某些其他方面的功能连接模式与与静息状态相关的皮质部分不对应。
