Dermatology and Andrology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Clinical Pathology Department, Medical Division, National Research Center, Cairo, Egypt.
Int J Dermatol. 2023 Jan;62(1):73-78. doi: 10.1111/ijd.16343. Epub 2022 Jul 6.
Psoriasis (Pso) is a chronic proliferative skin condition associated with hyperuricemia that may impair renal function.
The current study investigates the correlation between purine derivatives (PDs) and renal function in patients with Pso.
PATIENTS/METHODS: This case-control study comprises 30 psoriatic patients and 30 age- and sex-matched healthy controls. The enzyme-linked immunosorbent assay (ELISA) was used to assess serum xanthine oxidase (XO) and urine albumin levels. Serum uric acid (SUA) and urinary creatinine were measured using the colorimetric method.
There was a rise in the related PDs levels in patients with Pso compared to controls, as evidenced by the enhanced SUA levels (p < 0.001) and XO levels (p < 0.001). The presence of the related PDs in the serum was linked to the severity of Pso, and there was also a connection between the related PDs levels in the blood and indicators of renal dysfunction. Moreover, SUA and urinary albumin creatinine ratio (UACR) were found to be significantly correlated (r = 0.371 and p = 0.044), as were XO and UACR (r = 0.422 and p = 0.020). In psoriatic patients with itching and palmoplantar affection, mean SUA levels were considerably more significant than those in other instances (p = 0.005 and p = 0.018, respectively).
Pso, being a hyperproliferative disease, is associated with hyperuricemia, which has a harmful effect on kidney function. The related PDs may be unique serological biomarkers for patients with Pso who are at high risk of developing renal abnormalities, especially with higher severity scores.
银屑病（Pso）是一种与高尿酸血症相关的慢性增生性皮肤疾病，可能会损害肾功能。
本研究旨在探讨银屑病患者嘌呤衍生物（PDs）与肾功能之间的关系。
患者/方法：本病例对照研究纳入了 30 例银屑病患者和 30 名年龄和性别匹配的健康对照者。采用酶联免疫吸附试验（ELISA）检测血清黄嘌呤氧化酶（XO）和尿白蛋白水平，采用比色法检测血清尿酸（SUA）和尿肌酐。
与对照组相比，银屑病患者的相关 PDs 水平升高，表现为 SUA 水平（p<0.001）和 XO 水平（p<0.001）升高。血清中相关 PDs 的存在与银屑病的严重程度有关，血液中相关 PDs 水平与肾功能指标之间也存在关联。此外，SUA 与尿白蛋白肌酐比（UACR）呈显著相关（r=0.371，p=0.044），XO 与 UACR 也呈显著相关（r=0.422，p=0.020）。在有瘙痒和掌跖皮损的银屑病患者中，SUA 水平明显高于其他患者（p=0.005 和 p=0.018）。
银屑病作为一种高增殖性疾病，与高尿酸血症有关，后者对肾功能有不良影响。相关 PDs 可能是高尿酸血症风险较高的银屑病患者的独特血清学生物标志物，尤其是在疾病严重程度评分较高的患者中。
