Department of Chemistry, Faculty of Sciences, University of Birjand, Birjand 97175-615, Iran.
Department of Chemistry, Faculty of Science, University of Zabol, Zabol 98615-538, Iran.
Inorg Chem. 2022 Jul 18;61(28):10678-10693. doi: 10.1021/acs.inorgchem.2c00819. Epub 2022 Jul 6.
In this paper, a new Mn-based metal-organic framework [UoB-6] was obtained a one-step ultrasonic irradiation method with the ligand (Hbdda: 4,4'-(1,4-phenylenebis(azaneylylidene))bis(methaneylylidene))dibenzoic acid. The structural integrity of the synthesized BioMOF-Mn was corroborated by FT-IR, EDX, ICP, XRD, TEM, DLS, FESEM, and BET-BJH analyses. The aerobic oxidative domino reaction of benzyl alcohols or aldehydes with dimedone derivatives was performed in the presence of the UoB-6 catalyst to produce xanthene derivatives in good yields. Hot filtration and Hg poisoning tests proved the heterogeneous nature of the catalyst. Novel synthesized xanthene-based bis-aldehydes were introduced as potent HDAC1 inhibitors according to molecular docking calculations. Finally, the inhibitory activities of Mn-MOF nanoparticles were evaluated on and . The MIC, MBC, and MFC values were determined from 2048 to 4096 μg·mL according to antimicrobial susceptibility testing methods. The inhibitory effects of antimicrobial agents can be exacerbated when loaded on BioMOFs.
本文采用一步超声辐射法，以配体（Hbdda：4,4'-(1,4-亚苯基双（氮杂亚基）双（亚甲基亚基）二苯甲酸）合成了一种新型的 Mn 基金属有机骨架[UoB-6]。通过 FT-IR、EDX、ICP、XRD、TEM、DLS、FESEM 和 BET-BJH 分析证实了所合成的 BioMOF-Mn 的结构完整性。在 UoB-6 催化剂的存在下，苄醇或醛与二亚甲基二酮衍生物的有氧氧化 domino 反应进行，以高产率得到呫吨衍生物。热过滤和 Hg 中毒测试证明了催化剂的非均相性质。根据分子对接计算，新合成的基于呫吨的双醛被引入为有效的 HDAC1 抑制剂。最后，根据抗菌药敏试验方法，从 2048 到 4096 μg·mL-1 测定了 Mn-MOF 纳米颗粒对 和 的抑制活性。MIC、MBC 和 MFC 值分别从 2048 到 4096 μg·mL-1 确定。当负载在 BioMOFs 上时，抗菌剂的抑制作用可以增强。
