2010 年至 2019 年全球肝癌流行病学变化：NASH 是肝癌增长最快的病因。
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer.
机构信息
NAFLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore.
Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
出版信息
Cell Metab. 2022 Jul 5;34(7):969-977.e2. doi: 10.1016/j.cmet.2022.05.003. Epub 2022 Jun 3.
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burden remains unclear. We estimated global and regional temporal trends in the burden of liver cancer and the contributions of various liver disease etiologies using the methodology framework of the Global Burden of Disease study. Between 2010 and 2019, there was a 25% increase in liver cancer deaths. Age-standardized death rates (ASDRs) increased only in the Americas and remained stable or fell in all other regions. Between 2010 and 2019, non-alcoholic steatohepatitis (NASH) and alcohol had the fastest growing ASDRs, while HCV and HBV declined. Urgent measures are required at a global level to tackle underlying metabolic risk factors and slow the growing burden of NASH-associated liver cancer, especially in the Americas.
由于酒精消费的增加、肥胖患病率的上升以及乙型肝炎病毒 (HBV) 和丙型肝炎病毒 (HCV) 治疗的进步，肝癌的流行病学正在发生变化。然而，这些变化对全球肝癌负担的影响仍不清楚。我们使用全球疾病负担研究的方法框架，估计了肝癌负担的全球和区域时间趋势，以及各种肝病病因的贡献。2010 年至 2019 年间，肝癌死亡人数增加了 25%。标准化死亡率 (ASDR) 仅在美洲有所上升，而在所有其他地区保持稳定或下降。2010 年至 2019 年间，非酒精性脂肪性肝炎 (NASH) 和酒精的 ASDR 增长最快，而 HCV 和 HBV 则有所下降。需要在全球范围内采取紧急措施来解决潜在的代谢危险因素，减缓 NASH 相关肝癌的负担增长，尤其是在美洲。
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