Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Open Heart. 2022 Jul;9(2). doi: 10.1136/openhrt-2022-002056.
To examine workforce attachment among patients with congenital long QT syndrome (cLQTS) following diagnosis and identify factors associated with workforce attachment.
In this nationwide cohort study, all patients diagnosed with cLQTS in Denmark between 1996 and 2016 aged 18-60 years at diagnosis were identified using nationwide registries. Patients attached to the workforce at diagnosis were included. Attachment to the workforce 1 year after cLQTS diagnosis was examined and compared with a background population matched 1:4 on age, sex and employment status. Multiple logistic regression was performed to identify factors associated with 1-year workforce detachment among patients with cLQTS. 298 patients fulfilled the inclusion criteria. Six months after cLQTS diagnosis, 90.9% of patients with cLQTS were attached to the workforce compared with 95.0% in the background population (p=0.006 for difference). One year after diagnosis, 93.3% of patients with cLQTS were attached to the workforce compared with 93.8% in the background population (p=0.26). Among patients with cLQTS, a severe cLQTS disease manifestation was associated with workforce detachment 1 year after diagnosis (compared with asymptomatic patients; aborted cardiac arrest OR 20.4 (95% CI, 1.7 to 249.9); ventricular tachycardia/syncope OR 10.9 (95% CI, 1.1 to 110.5)). No other associated factors were identified.
More than 90% of patients with cLQTS remained attached to the workforce 1 year after diagnosis, which was similar to a matched background population. Patients with a severe cLQTS disease manifestation were less likely to be attached to the workforce 1 year after diagnosis.
研究先天性长 QT 综合征（cLQTS）患者确诊后的劳动力依附情况，并确定与劳动力依附相关的因素。
在这项全国性队列研究中，通过全国性登记册确定了丹麦在 1996 年至 2016 年间诊断为 cLQTS 的所有 18-60 岁患者。包括在诊断时依附于劳动力的患者。检查 cLQTS 诊断后 1 年的劳动力依附情况，并与年龄、性别和就业状况匹配的背景人群进行比较。采用多因素逻辑回归分析确定 cLQTS 患者 1 年劳动力分离的相关因素。298 名患者符合纳入标准。cLQTS 诊断后 6 个月，90.9%的患者依附于劳动力，而背景人群为 95.0%（差异有统计学意义，p=0.006）。诊断 1 年后，93.3%的患者依附于劳动力，而背景人群为 93.8%（差异无统计学意义，p=0.26）。在 cLQTS 患者中，严重的 cLQTS 疾病表现与诊断 1 年后劳动力分离相关（与无症状患者相比；心搏骤停中止 OR 20.4（95%CI，1.7 至 249.9）；室性心动过速/晕厥 OR 10.9（95%CI，1.1 至 110.5））。未确定其他相关因素。
超过 90%的 cLQTS 患者在诊断后 1 年内仍依附于劳动力，与匹配的背景人群相似。严重 cLQTS 疾病表现的患者在诊断后 1 年内附着于劳动力的可能性较小。
