Teh Carren Sui-Lin, Abdullah Nurul Ain, Kamaruddin Noor Rafidah, Mohd Judi Kamariah Binti, Fadzilah Ismail, Zainun Zuraida, Prepageran Narayanan
Department of Otorhinolaryngology, Hospital Sungai Buloh, Jalan Hospital, Sungai Buloh, Selangor, Malaysia.
School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Ann Otol Rhinol Laryngol. 2023 May;132(5):566-577. doi: 10.1177/00034894221111408. Epub 2022 Jul 6.
Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder where there is persistent dizziness or unsteadiness occurring on most days for more than 3 months duration. Treatment recommendations for PPPD include vestibular rehabilitation therapy (VRT) with or without medications and/or cognitive behavioral therapy.
This paper is a pilot study designed to compare the effects of Bal Ex as a home-based VRT on the quality of life (EQ-5D), dizziness handicap (DHI) and mental health (DASS-21) against hospital-based VRT.
This was an assessor-blinded, randomized controlled pilot study where PPPD patients were randomly selected to undergo Bal Ex, the home-based VRT (intervention group) or hospital-based (control group) VRT. The participants were reviewed at 4 weeks and 12 weeks after the start of therapy to assess the primary endpoints using the subjective improvement in symptoms as reported by patients, changes in DHI scores, DASS-21 scores and EQ5D VAS scores.
Thirty PPPD patients successfully completed the study with 15 in each study group. Within 4 weeks, there were significant improvements in the total DHI scores as well as anxiety levels. By the end of 12 weeks, there were significant improvements in the DHI, DASS-21 and EQ5D. The degree of improvement between Bal Ex and the control was comparable.
VRT is an effective modality in significantly improving quality of life, dizziness handicap, depression, and anxiety levels within 3 months in PPPD. Preliminary results show Bal Ex is as effective as hospital-based VRT and should be considered as a treatment option for PPPD.
持续性姿势 - 感知性头晕(PPPD)是一种慢性功能性前庭疾病,多数日子里都会持续出现头晕或不稳,持续时间超过3个月。PPPD的治疗建议包括采用或不采用药物的前庭康复治疗(VRT)和/或认知行为疗法。
本文是一项前瞻性研究,旨在比较以家庭为基础的VRT——平衡训练(Bal Ex)与以医院为基础的VRT对生活质量(EQ - 5D)、头晕障碍(DHI)和心理健康(DASS - 21)的影响。
这是一项评估者盲法、随机对照的前瞻性研究,PPPD患者被随机选择接受平衡训练(Bal Ex),即家庭式VRT(干预组)或医院式(对照组)VRT。在治疗开始后的4周和12周对参与者进行复查,以患者报告的症状主观改善情况、DHI评分变化、DASS - 21评分变化和EQ5D视觉模拟量表(VAS)评分来评估主要终点。
30例PPPD患者成功完成研究,每个研究组各有15例。在4周内,DHI总分以及焦虑水平有显著改善。到12周结束时,DHI、DASS - 21和EQ5D均有显著改善。平衡训练(Bal Ex)组与对照组之间的改善程度相当。
VRT是一种有效方式,能在3个月内显著改善PPPD患者的生活质量、头晕障碍、抑郁和焦虑水平。初步结果表明,平衡训练(Bal Ex)与医院式VRT效果相同,应被视为PPPD的一种治疗选择。