核转运蛋白α2在宫颈小细胞癌中的过表达与预后不良相关。
Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.
作者信息
Liao Ling-Min, Gu Zhen-Bang, Fang Ming, Yao Gong-Ji, Huang Long
机构信息
The Second Afiliated Hospital of Nanchang University Nanchang, China.
Jiangxi Key Laboratory of Clinical and Translational Cancer Research Jiangxi, China.
出版信息
Int J Clin Exp Pathol. 2022 Jun 15;15(6):241-246. eCollection 2022.
BACKGROUND
Cervical small cell carcinoma (SCCC) is uncommon and little is known about its molecular markers. Karyopherin α2 (KPNA2) has been demonstrated in a variety of malignancies. Our objective was to determine whether the KPNA2 level is predictive of clinical outcome in patients with SCCC.
METHODS
We detected KPNA2 expression by immunohistochemistry in SCCC tumors from 62 patients. The staining results were evaluated by H-score. The correlation among KPNA2 expression level, clinical characteristics, and prognosis was analyzed.
RESULTS
KPNA2 expression was detected in tumor tissue from 55 patients with SCCC (55/62, 89%). High KPNA2 expression correlated significantly with International Federation of Gynecology and Obstetrics staging (P=0.035), tumor size (P=0.019), poorer overall survival (OS) (P=0.008), and poorer disease-free survival (P=0.004) compared to low KPNA2 expression. Multivariate analysis showed that KPNA2 expression level (P=0.037) and tumor size (P=0.046) were independent prognostic factors of OS.
CONCLUSIONS
KPNA2 may be a molecular marker and indicator of prognosis in SCCC.
背景
宫颈小细胞癌（SCCC）并不常见，对其分子标志物了解甚少。核转运蛋白α2（KPNA2）已在多种恶性肿瘤中得到证实。我们的目的是确定KPNA2水平是否可预测SCCC患者的临床结局。
方法
我们通过免疫组织化学检测了62例SCCC患者肿瘤组织中的KPNA2表达。染色结果采用H评分进行评估。分析了KPNA2表达水平、临床特征和预后之间的相关性。
结果
在55例SCCC患者的肿瘤组织中检测到KPNA2表达（55/62，89%）。与低KPNA2表达相比，高KPNA2表达与国际妇产科联盟分期（P=0.035）、肿瘤大小（P=0.019）、较差的总生存期（OS）（P=0.008）和较差的无病生存期（P=0.004）显著相关。多因素分析显示，KPNA2表达水平（P=0.037）和肿瘤大小（P=0.046）是OS的独立预后因素。
结论
KPNA2可能是SCCC的一种分子标志物和预后指标。
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