Neiman J C, Mant M J, Shnitka T K
Arch Pathol Lab Med. 1987 Jun;111(6):563-5.
Phagocytosis of platelets by Kupffer cells has long been suspected in immune thrombocytopenia. We describe a patient with Hodgkin's disease who also had immune thrombocytopenia. Surface localization studies with chromium 51-labeled platelets showed predominant hepatic localization of radioactivity, and the thrombocytopenia did not respond to splenectomy. Subsequent chemotherapy with immunosuppressive drugs led to remission of the thrombocytopenia. In this patient, phagocytosis of platelets by Kupffer cells was demonstrated by electron microscopy, and the degree of platelet phagocytosis in the liver was greater than in the spleen. This provides direct evidence that, at least in some cases of immune thrombocytopenia, platelets are phagocytosed by Kupffer cells.
长期以来，人们一直怀疑库普弗细胞对血小板的吞噬作用与免疫性血小板减少症有关。我们描述了一名患有霍奇金病且同时患有免疫性血小板减少症的患者。用铬51标记血小板进行的表面定位研究显示，放射性主要定位于肝脏，且血小板减少症对脾切除术无反应。随后使用免疫抑制药物进行化疗使血小板减少症得到缓解。在该患者中，通过电子显微镜证实了库普弗细胞对血小板的吞噬作用，并且肝脏中血小板的吞噬程度大于脾脏。这提供了直接证据，表明至少在某些免疫性血小板减少症病例中，血小板是被库普弗细胞吞噬的。
