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杜氏肌营养不良症的脊柱侧凸治疗:改良朱厄特过伸支具的前瞻性研究

Scoliosis management in Duchenne muscular dystrophy: prospective study of modified Jewett hyperextension brace.

作者信息

Colbert A P, Craig C

出版信息

Arch Phys Med Rehabil. 1987 May;68(5 Pt 1):302-4.

PMID:3579538
Abstract

The management of scoliosis in Duchenne muscular dystrophy is not standardized. Some centers offer no treatment, some provide customized body jackets or wheelchair inserts, and others recommend early surgical spinal fusion. Spinal orthoses are frequently prescribed at significant cost and inconvenience to the patient, with little evidence as to effectiveness in preventing scoliosis. This paper reports the preliminary findings of 22 patients involved in a study assessing the usefulness of a modified Jewett hyperextension brace. Seven brace wearers and 15 controls were entered into the study. The preliminary results indicate a mean curvature of 23.6 degrees (+/- 12.8 degrees) in the experimental group and 35.7 degrees (+/- 24.8 degrees) in the controls. Over an observation period ranging from two to seven years, the wearers have shown an average curve progression of 8.8 degrees/yr while the control group progressed at 11.2 degrees/yr. This difference is not considered statistically significant. We conclude that wearing the brace minimally slows scoliosis progression, but does not ultimately prevent a significant curve.

摘要

杜氏肌营养不良症脊柱侧弯的治疗方法并不规范。一些中心不提供任何治疗,一些中心提供定制的身体夹克或轮椅衬垫,还有一些中心则建议早期进行脊柱融合手术。脊柱矫形器的处方很常见,这给患者带来了高昂的费用和不便,而且几乎没有证据表明其在预防脊柱侧弯方面的有效性。本文报告了22名参与一项评估改良朱厄特伸展支具效用研究的患者的初步结果。7名支具佩戴者和15名对照者参与了该研究。初步结果显示,实验组的平均弯曲度为23.6度(±12.8度),对照组为35.7度(±24.8度)。在长达两到七年的观察期内,佩戴者的侧弯平均进展速度为每年8.8度,而对照组为每年11.2度。这种差异在统计学上不被认为具有显著性。我们得出结论,佩戴支具只能在最小程度上减缓脊柱侧弯的进展,但最终无法阻止明显的侧弯。

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Scoliosis management in Duchenne muscular dystrophy: prospective study of modified Jewett hyperextension brace.杜氏肌营养不良症的脊柱侧凸治疗:改良朱厄特过伸支具的前瞻性研究
Arch Phys Med Rehabil. 1987 May;68(5 Pt 1):302-4.
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A population-based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet).一项基于人群的研究显示,在肌肉营养不良监测、跟踪和研究网络(MD STARnet)诊断出的肌营养不良症男性中,脊柱侧凸的发病率较高。
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Spinal Deformities and Advancement in Corrective Orthoses.
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Bioengineering (Basel). 2020 Dec 25;8(1):2. doi: 10.3390/bioengineering8010002.
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Surgery for scoliosis in Duchenne muscular dystrophy.杜氏肌营养不良症脊柱侧弯的手术治疗
Cochrane Database Syst Rev. 2015 Oct 1;2015(10):CD005375. doi: 10.1002/14651858.CD005375.pub4.
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Surgical treatment of spinal deformities in Duchenne muscular dystrophy: a long term follow-up study.杜氏肌营养不良症脊柱畸形的外科治疗:一项长期随访研究
Eur Spine J. 2004 Aug;13(5):441-8. doi: 10.1007/s00586-002-0515-6. Epub 2004 Apr 24.
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Lung function in Duchenne muscular dystrophy.杜氏肌营养不良症中的肺功能
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