Lin Hong-Yu, Wei Qing-Qing, Huang Jian-Yi, Pan Xing-Hua, Liang Ning-Chao, Huang Cai-Xia, Long Teng, Gao Wen, Shi Sheng-Liang
Department of Neurology, People's Hospital of Chongzuo City, Chongzuo, China.
Department of Neurology, People's Hospital of Liuzhou City, Liuzhou, China.
Front Neurol. 2022 Jun 20;13:922677. doi: 10.3389/fneur.2022.922677. eCollection 2022.
The relationship between mortality and seizures after intracerebral hemorrhage (ICH) has not yet been understood until now. A meta-analysis was performed to assess the effect of post-ICH seizures on mortality among patients with ICH.
PubMed and Embase were searched from the establishment of the databases to December 2021 to identify literature that evaluated the relationship between post-ICH seizures and mortality in ICH. Crude odds ratios and adjusted odds ratios with a 95% confidence interval (CI) were pooled using a random-effects model.
Thirteen studies involving 245,908 participants were eventually included for analysis. The pooled estimate suggested that post-ICH seizures were not associated with significantly increased mortality in patients with ICH (crude odds ratios 1.35, 95% CI: 0.91-2; adjusted adds ratios 1.22, 95% CI: 0.78-1.88). However, the relationship was not consistent in subgroup analysis or robust in a sensitivity analysis.
This meta-analysis proved that post-ICH seizures were not associated with significantly increased mortality in patients with ICH. However, this result could be influenced by confounding factors, so more high-quality research is needed.
迄今为止，脑出血（ICH）后死亡率与癫痫发作之间的关系尚未明确。进行了一项荟萃分析，以评估脑出血后癫痫发作对脑出血患者死亡率的影响。
检索了从数据库建立至2021年12月的PubMed和Embase数据库，以识别评估脑出血后癫痫发作与脑出血患者死亡率之间关系的文献。使用随机效应模型汇总了粗比值比和调整后的比值比以及95%置信区间（CI）。
最终纳入13项研究，共245,908名参与者进行分析。汇总估计表明，脑出血后癫痫发作与脑出血患者死亡率显著增加无关（粗比值比1.35，95%CI：0.91 - 2；调整后比值比1.22，95%CI：0.78 - 1.88）。然而，在亚组分析中这种关系并不一致，在敏感性分析中也不稳健。
这项荟萃分析证明，脑出血后癫痫发作与脑出血患者死亡率显著增加无关。然而，这一结果可能受到混杂因素的影响，因此需要更多高质量的研究。
