From the Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Menopause. 2022 Jul 1;29(7):850-855. doi: 10.1097/GME.0000000000001987.
The primary objective was to investigate the association between early menopause and cardiovascular disease (CVD) prevalence in Japanese women. The secondary objective was to ascertain the association with CVD risk factors.
In this cross-sectional study, 7,239 naturally menopausal women from the Yamagata Cohort Study who completed an annual health visit and questionnaire between 2009 and 2015 were divided into three groups according to their age at menopause (women experiencing menopause at <45, 45-49 y, and ≥ 50 y). The diagnosis of coronary heart disease (CHD) and stroke were made by self-report, while hypertension, hyperlipidemia, and diabetes mellitus, were diagnosed by vital signs and laboratory parameters. Logistic regression analysis was used to estimate the associations between age at menopause and CVD prevalence and CVD risk factors.
A total of 354 (4.9%) and 156 (2.2%) women reported a history of CHD and stroke, respectively. Women experiencing menopause at <45 years had a higher prevalence of CHD than those experiencing menopause at ≥50 years (OR 1.77, 95% CI 1.07-2.90; P = 0.023). Stroke, hypertension, diabetes mellitus, and hyperlipidemia were equally prevalent among the three groups. Significant interactions were observed between age at menopause and body mass index (BMI) (P = 0.025) and parity (P = 0.025). Among those with a BMI < 18.5 or parity ≥2, women experiencing menopause at <45 years had a significantly higher prevalence of CHD than those experiencing menopause at ≥50 years.
Early menopause and low BMI were associated with CHD in Japanese women.
本研究旨在探讨日本女性绝经年龄与心血管疾病（CVD）患病率之间的关系，并确定与 CVD 相关危险因素的关系。
本横断面研究纳入了参加 2009 年至 2015 年年度健康检查和问卷调查的 7239 名自然绝经女性，根据绝经年龄将其分为三组（<45 岁、45-49 岁和≥50 岁）。冠心病和脑卒中的诊断通过自我报告，高血压、高血脂和糖尿病则通过生命体征和实验室参数进行诊断。采用 logistic 回归分析评估绝经年龄与 CVD 患病率及 CVD 相关危险因素之间的关系。
共有 354 名（4.9%）和 156 名（2.2%）女性报告有冠心病和脑卒中病史。与绝经年龄≥50 岁的女性相比，<45 岁绝经的女性冠心病患病率更高（OR 1.77，95%CI 1.07-2.90；P = 0.023）。三组之间脑卒中、高血压、糖尿病和高血脂的患病率相似。绝经年龄与体重指数（BMI）（P = 0.025）和产次（P = 0.025）之间存在显著交互作用。在 BMI<18.5 或产次≥2 的女性中，<45 岁绝经的女性冠心病患病率明显高于≥50 岁绝经的女性。
在日本女性中，早绝经和低 BMI 与冠心病有关。
