婴儿和幼儿的单剂疫苗接种对流感疾病提供适度的保护，这种保护在 5 个月后会减弱。
Single-Dose Vaccination Among Infants and Toddlers Provides Modest Protection Against Influenza Illness, Which Wanes After 5 Months.
机构信息
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Sustainable Sciences Institute, Managua, Nicaragua.
出版信息
J Infect Dis. 2022 Dec 28;227(1):87-91. doi: 10.1093/infdis/jiac288.
Abstract
In their first season of vaccination, young children are recommended 2 doses of influenza vaccine, but a 2-dose schedule might be difficult to implement in many countries. Within a cohort study of 742 children aged 6 to <24 months in Managua, Nicaragua, this study estimated effectiveness of partial vaccination from 3 to 9 months postvaccination. Vaccine effectiveness was 74% (95% confidence interval [CI], 24%-91%) within 3 months and 55% (95% CI, 10%-77%) within 4 months. There was not significant protection beyond 5 months. Partial vaccination might confer some benefits but should be followed by a second dose.
摘要
在接种疫苗的第一个季节，建议幼儿接种 2 剂流感疫苗，但在许多国家，2 剂接种方案可能难以实施。在尼加拉瓜马那瓜的一项针对 6 至<24 个月大的 742 名儿童的队列研究中，本研究估计了 3 至 9 个月后部分接种疫苗的效果。疫苗有效性在 3 个月内为 74%（95%置信区间[CI]，24%-91%），在 4 个月内为 55%（95% CI，10%-77%）。5 个月后没有显著的保护作用。部分接种可能会带来一些益处，但随后应接种第二剂。
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