Department of Oral and Maxillofacial Surgery, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
J Cancer Res Clin Oncol. 2023 Apr;149(4):1607-1619. doi: 10.1007/s00432-022-04143-6. Epub 2022 Jul 7.
In the course of tumor progression, cancer clones interact with host normal cells, and these interactions make them under selection pressure all the time. Cell competition, which can eliminate suboptimal cells and optimize organ development via comparison of cell fitness information, is found to take place between host cells and transformed cells in mammals and play important roles in different phases of tumor progression. The aim of this study is to summarize the current knowledge about the roles and corresponding mechanisms of different cell competition interactions between host normal cells and transformed cells involved in mammalian tumor development.
We reviewed the published relevant articles in the Pubmed.
So far, the role of several cell competition interactions have been well described in the different phases of mammalian tumor genesis and development. While cell competitions for trophic factors and epithelial defense against cancer (EDAC) prevent the emergence of transformed cells and suppress carcinogenesis, fitness-fingerprints-comparison system and Myc supercompetitors promote the local expansion of transformed cells after the early tumor lesion is formatted. In addition, various preclinical tumor-suppression models which based on the molecular mechanisms of these competition interactions show potential clinical value of boosting the fitness of host normal cells.
Cell competition between host and transformed cells has pleiotropic effects in mammalian tumor genesis and development. The clarification of specific molecular mechanisms shed light on novel ideas for the prevention and treatment of cancer.
在肿瘤进展过程中，癌细胞克隆与宿主正常细胞相互作用，这些相互作用使它们始终处于选择压力之下。细胞竞争可以通过比较细胞适应度信息来消除次优细胞并优化器官发育，在哺乳动物中发现宿主细胞和转化细胞之间存在细胞竞争，并在肿瘤进展的不同阶段发挥重要作用。本研究旨在总结宿主正常细胞与转化细胞之间不同细胞竞争相互作用在哺乳动物肿瘤发生和发展中的作用和相应机制的最新知识。
我们在 Pubmed 上查阅了已发表的相关文章。
到目前为止，几种细胞竞争相互作用在哺乳动物肿瘤发生和发展的不同阶段的作用已经得到了很好的描述。虽然营养因子竞争和上皮防御抗癌（EDAC）防止转化细胞的出现并抑制致癌作用，但是适应性指纹比较系统和 Myc 超级竞争者促进了早期肿瘤病变形成后转化细胞的局部扩张。此外，基于这些竞争相互作用的分子机制的各种临床前肿瘤抑制模型显示出提高宿主正常细胞适应性的潜在临床价值。
宿主与转化细胞之间的细胞竞争在哺乳动物肿瘤发生和发展中具有多效性。特定分子机制的阐明为癌症的预防和治疗提供了新的思路。
