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多重疾病、新冠肺炎与心理健康:加拿大老龄化纵向研究(CLSA)的纵向分析

Multimorbidity, COVID-19 and Mental Health: Canadian Longitudinal Study on Aging (CLSA) Longitudinal Analyses.

作者信息

Wister Andrew, Li Lun, Best John R, Cosco Theodore D, Kim Boah

机构信息

Gerontology Research Centre & Department of Gerontology, Simon Fraser University, Burnaby, British Columbia, Canada.

Gerontology Research Centre, Simon Fraser University, Burnaby, British Columbia, Canada.

出版信息

Clin Gerontol. 2023 Jan-Dec;46(5):729-744. doi: 10.1080/07317115.2022.2094742. Epub 2022 Jul 7.

DOI:10.1080/07317115.2022.2094742
PMID:35797007
Abstract

OBJECTIVES

This paper examines the longitudinal effects of the COVID-19 pandemic on older adults (65+) with multimorbidity on levels of depression, anxiety, and perceived global impact on their lives.

METHODS

Baseline (2011-2015) and Follow-up 1 (2015-2018) data from the Canadian Longitudinal Study on Aging (CLSA), and the Baseline and Exit waves of the CLSA COVID-19 study (April-December, 2020) (n = 18,099). Multimorbidity was measured using: a) an additive scale of chronic conditions; and b) six chronic disease clusters. Linear Mixed Models were employed to test hypotheses.

RESULTS

Number of chronic conditions pre-pandemic was associated with pandemic levels of depression (estimate = 0.40, 95% CI: [0.37,0.44]); anxiety (estimate = 0.20, 95% CI: [0.18, 0.23]); and perceived negative impact of the pandemic (OR = 1.04, 95% CI: [1.02, 1.06]). The associations between multimorbidity and anxiety decreased during the period of the COVID-19 surveys (estimate = -0.02, 95% CI: [-0.05, -0.01]); whereas the multimorbidity association with perceived impact increased (OR = 1.03, 95% CI: [1.01, 1.05]).

CONCLUSIONS

This study demonstrates that pre-pandemic multimorbidity conditions are associated with worsening mental health.

CLINICAL IMPLICATIONS

Clinicians treating mental health of older adults need to consider the joint effects of multimorbidity conditions and pandemic experiences to tailor counseling and other treatment protocols.

摘要

目的

本文探讨了新冠疫情对患有多种疾病的老年人(65岁及以上)的抑郁、焦虑水平以及对其生活的总体影响的纵向效应。

方法

来自加拿大老龄化纵向研究(CLSA)的基线数据(2011 - 2015年)和随访1数据(2015 - 2018年),以及CLSA新冠研究的基线和结束阶段数据(2020年4月 - 12月)(n = 18,099)。使用以下方法测量多种疾病:a)慢性病累加量表;b)六个慢性病集群。采用线性混合模型来检验假设。

结果

疫情前慢性病的数量与疫情期间的抑郁水平相关(估计值 = 0.40,95%置信区间:[0.37, 0.44]);焦虑水平相关(估计值 = 0.20,95%置信区间:[0.18, 0.23]);以及疫情的负面感知影响相关(比值比 = 1.04,95%置信区间:[1.02, 1.06])。在新冠疫情调查期间,多种疾病与焦虑之间的关联有所下降(估计值 = -0.02,95%置信区间:[-0.05, -0.01]);而多种疾病与感知影响之间的关联有所增加(比值比 = 1.03,95%置信区间:[1.01, 1.05])。

结论

本研究表明,疫情前的多种疾病状况与心理健康恶化有关。

临床意义

治疗老年人心理健康的临床医生需要考虑多种疾病状况和疫情经历的联合效应,以制定咨询和其他治疗方案。

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