Kaleda V G, Tikhonov D V
Mental Health Research Centre, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(6. Vyp. 2):17-21. doi: 10.17116/jnevro202212206217.
To identify psychopathological features of postpsychotic depressions formed within the achievement of remission after the first psychotic episode in adolescence.
Fifty-six male patients of adolescent age (average age 19.7±2.5 years) with postpsychotic depression (F20, F25) were enrolled. The study used clinical-psychopathological, psychometric and statistical methods. HDRS-21 was used for psychometric assessment of depressive symptoms, and suicidal risk was assessed using SSI.
There were two types of post-psychotic depression: type 1 with a positive affectivity (58.93%, =33) and type 2 with negative affectivity (41.07%, =23). Significant differences in the structure of the first psychosis were found (χ=7.8; =0.02). In the case of depression type 1, the HDRS-21 score was 17.49±7.49 points with the largest number of points on the sub-scales «low mood» (2.81±0.83) and «mental anxiety» (2.88±0.45). The SSI average score was 7.81±6.46. Anti-vital thinking was noted by 75.76% (=25). In the case of depression type 2, the HDRS-21 average score was 23.68±9.24 points (the largest number of points was fixed in the sub-scales «low mood» - 2.44±0.73, «work and activity» - 3.19±0.89). The SSI average score was 12.30±8.47.
The study showed the heterogeneity of the course of postpsychotic depressions that occur after a manifest psychotic episode of adolescence. Differences in the structure of depression were identified, which are important for therapeutic tactics and prognosis of the disease.