Iznak A F, Iznak E V, Damyanovich E V, Oleichik I V
Mental Health Research Centre, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(6. Vyp. 2):30-35. doi: 10.17116/jnevro202212206230.
To determine EEG markers of depression severity and clarify the brain mechanisms of heboid depression by identifying relationships between clinical and neurophysiological parameters in female adolescents with heboid depression.
A clinical-neurophysiological study of 25 female adolescents, aged 16-25 years, mean age 18.7±2.6 years, with heboid depression (ICD-10 items F31.3-F31.4, F34.0) was carried out. The severity of depressive disorders during hospitalization varied from mild to severe - the HDRS-17 total score ranged from 12 to 37 points (average 26.4±6.5 points). To assess the functional state of the brain, a multichannel EEG recording was performed in a state of calm wakefulness with closed eyes (for 2-3 minutes). EEG was recorded in 16 leads: F7, F3, F4, F8, T3, C3, Cz, C4, T4, T5, P3, Pz, P4, T6, O1 and O2. Data analysis was carried out using descriptive and nonparametric statistics programs from the IBM SPSS Statistics, v.22 package.
Differences in the EEG of patients from the norm were detected in the alpha frequency range, SpM values of the alpha2 subrange (9-11 Hz) were statistically significantly lower in the frontal areas (in the left frontal lead F3 =0.021, in the right frontal lead F4 =0.006). The patients did not have «highly coherent» (Coh >0.80) interhemispheric connections between the frontal-central-anterotemporal regions of the left and right hemispheres in the frequency range of the alpha-rhythm (8-13 Hz). The following correlations (≤0.05) were revealed: the values of the HDRS-17 total score were positively correlated with the spectral power values of theta1 (4-6 Hz) and theta2 (6-8 Hz) EEG frequency subranges only in the frontal, central and midtemporal leads from the right hemisphere (F4, C4, T4).
In patients with heboid depression, there is a functional «uncoupling» of the frontal-central-anterior-temporal areas of the right and left hemispheres of the brain. It is possible that such a «dissociation» and a relatively large activation of the anterior parts of the left rather than the right hemisphere play a role in the weak control of impulsive delinquent behavior in patients with heboid depression. The identified atypical features of the EEG spatial organization and correlations of the EEG frequency structure with clinical parameters are consistent with the atypical clinical picture of heboid depression.
通过确定青少年女性类木僵型抑郁症患者临床和神经生理参数之间的关系，来确定抑郁症严重程度的脑电图标志物，并阐明类木僵型抑郁症的脑机制。
对25名年龄在16 - 25岁、平均年龄18.7±2.6岁的青少年女性类木僵型抑郁症患者（国际疾病分类第10版条目F31.3 - F31.4、F34.0）进行了临床神经生理学研究。住院期间抑郁障碍的严重程度从轻度到重度不等——汉密尔顿抑郁量表-17项总分在12至37分之间（平均26.4±6.5分）。为评估大脑的功能状态，在静息闭眼状态下进行了多通道脑电图记录（持续2 - 3分钟）。脑电图记录了16个导联：F7、F3、F4、F8、T3、C3、Cz、C4、T4、T5、P3、Pz、P4、T6、O1和O2。使用IBM SPSS Statistics v.22软件包中的描述性和非参数统计程序进行数据分析。
在α频率范围内检测到患者脑电图与正常情况存在差异，α2子范围（9 - 11Hz）的慢波功率值在额叶区域在统计学上显著降低（左额叶导联F3 = 0.021，右额叶导联F4 = 0.006）。在α节律（8 - 13Hz）频率范围内，患者左右半球额叶 - 中央 - 前颞叶区域之间不存在“高度相干”（相干性> 0.80）的半球间连接。发现了以下相关性（≤0.05）：汉密尔顿抑郁量表-17项总分值仅在右半球的额叶、中央和颞中导联（F4、C4、T4）与脑电图频率子范围θ1（4 - 6Hz）和θ2（6 - 8Hz）的频谱功率值呈正相关。
在类木僵型抑郁症患者中，大脑左右半球的额叶 - 中央 - 前颞叶区域存在功能性“解耦”。这种“分离”以及左半球而非右半球前部相对较大的激活可能在类木僵型抑郁症患者对冲动性违法行为的控制减弱中起作用。所确定的脑电图空间组织的非典型特征以及脑电图频率结构与临床参数的相关性与类木僵型抑郁症的非典型临床症状一致。
