Galkin S A, Kornetova E G, Oshkina T A, Kornetov A N, Lebedeva V F, Bokhan N A
Mental Health Research Institute - Tomsk National Research Medical Center Russian Academy of Science, Tomsk, Russia.
Siberian State Medical University, Tomsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2024;124(2):123-128. doi: 10.17116/jnevro2024124021123.
To establish the relationships of functional changes of the brain of patients with schizophrenia with clinical manifestations of the disease and their constitutional and morphological features.
One hundred and eighteen patients with schizophrenia (64 men and 54 women), aged 33 [29; 40], years were examined. The following clinical and dynamic parameters were used: age of manifestation of the disease, duration of the disease, severity of clinical and psychopathological symptoms according to the PANSS. The anthropometric examination of patients was carried out according to V.V. Bunak's method in V.P. Chitetsov's modification for adult samples with calculation of Rees-Eysenk and Tanner indices. The EEG was recorded and analyzed in a state of calm, relaxed wakefulness with closed eyes with the calculation of the absolute spectral power for theta (4-7 Hz), alpha (8-13 Hz) and beta (14-30 Hz) rhythms.
Significant (<0.05) direct correlations between the age of the disease manifestation and the spectral power of the beta rhythm in the frontal leads (Fp1, Fp2, F3 and F4) were revealed. Inverse correlations (<0.05) were found between the duration of the disease in patients with schizophrenia and the spectral power of the alpha rhythm in the left temporal (T3) and right central leads (C4), the spectral power of the beta rhythm in the parietal-occipital (P3, P4, O1,O2) and temporal leads (T3, T4, T5), the spectral power of the theta rhythm in the left occipital (O1) and posterior temporal leads (T5). Significant inverse correlations were also found between the Tanner index and the spectral power of the alpha rhythm in the frontal and temporal leads, between the Rees-Eysenk index and the spectral power of the theta rhythm in the frontal leads.
The results indicate the presence of the conjugation of functional changes in the brain of patients with schizophrenia with clinical manifestations of the disease and their constitutional and morphological features. Thus, the assessment of the functional state of the central nervous system in patients with schizophrenia is an important component of the diagnostic search.
建立精神分裂症患者大脑功能变化与疾病临床表现及其体质和形态特征之间的关系。
对118例精神分裂症患者（64例男性和54例女性）进行检查，年龄为33[29；40]岁。使用了以下临床和动态参数：疾病表现年龄、病程、根据阳性和阴性症状量表（PANSS）评估的临床和精神病理症状严重程度。按照V.V.布纳克的方法并经V.P.奇捷佐夫修改后，对成年样本进行患者人体测量检查，计算里斯 - 艾森克和坦纳指数。在闭眼平静、放松的清醒状态下记录并分析脑电图，计算θ（4 - 7Hz）、α（8 - 13Hz）和β（14 - 30Hz）节律的绝对频谱功率。
发现疾病表现年龄与额区导联（Fp1、Fp2、F3和F4）β节律的频谱功率之间存在显著（<0.05）正相关。在精神分裂症患者中，病程与左颞区（T3）和右中央导联（C4）α节律的频谱功率、顶枕区（P3、P4、O1、O2）和颞区导联（T3、T4、T5）β节律的频谱功率、左枕区（O1）和后颞区导联（T5）θ节律的频谱功率之间存在负相关（<0.05）。还发现坦纳指数与额区和颞区导联α节律的频谱功率之间、里斯 - 艾森克指数与额区导联θ节律频谱功率之间存在显著负相关。
结果表明精神分裂症患者大脑功能变化与疾病临床表现及其体质和形态特征之间存在关联。因此，评估精神分裂症患者中枢神经系统的功能状态是诊断探索的重要组成部分。
