纳武利尤单抗和伊匹单抗治疗黑色素瘤儿童患者后引起的药物诱导超敏反应综合征/药物伴嗜酸性粒细胞增多和全身症状。
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms following nivolumab and ipilimumab in a pediatric patient with melanoma.
机构信息
School of Medicine, Wayne State University, Detroit, Michigan, USA.
Department of Dermatology, Wayne State University, Detroit, Michigan, USA.
出版信息
Pediatr Dermatol. 2022 May;39(3):486-487. doi: 10.1111/pde.14940.
PMID:35797209
Abstract
Drug-induced hypersensitivity syndrome (DIHS) is a type of severe cutaneous adverse reaction (SCAR). DIHS typically occurs 2-6 weeks after initiation of the offending medication. We report a case of DIHS in a pediatric patient undergoing treatment of metastatic melanoma with nivolumab and ipilimumab.
摘要
药物诱导的超敏反应综合征（DIHS）是一种严重的皮肤不良反应（SCAR）。DIHS 通常在开始使用致病药物后 2-6 周发生。我们报告了一例接受 nivolumab 和 ipilimumab 治疗转移性黑色素瘤的儿科患者发生 DIHS 的病例。
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