足部溃疡中的非产毒株白喉棒状杆菌。
Non-toxigenic Corynebacterium diphtheriae in hallux ulceration.
机构信息
Medical Biology Laboratory, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.
出版信息
J Infect Dev Ctries. 2022 Jun 30;16(6):1118-1121. doi: 10.3855/jidc.16153.
INTRODUCTION
Toxigenic Corynebacterium diphtheriae causes classical diphtheria. Skin infections by toxigenic or non-toxigenic Corynebacterium diphtheriae are prevalent in the tropics but are rarely reported.
CASE PRESENTATION
We report the identification of a non-toxigenic Corynebacterium diphtheriae (biovar Gravis) isolate in a 52-year-old Cambodian male. The patient presented purulent and non-healing ulcerations on the right hallux. The wound has healed after 7 days of antibiotic therapy with a favourable outcome.
CONCLUSIONS
This case represents, to our knowledge, the first report of Corynebacterium diphtheriae in Cambodia in the last 10 years, and highlights the lack of diagnosis and notifications of diphtheria. It is important to raise awareness among clinicians and to set up diphtheria surveillance in Cambodia.
介绍
产毒白喉棒状杆菌可引起典型白喉。产毒或非产毒白喉棒状杆菌引起的皮肤感染在热带地区很常见，但很少有报道。
病例介绍
我们报告了一例 52 岁柬埔寨男性中非产毒白喉棒状杆菌（苍白亚种）分离株的鉴定。患者右大足趾出现脓性和不愈合的溃疡。经过 7 天的抗生素治疗，伤口愈合，结果良好。
结论
据我们所知，这是过去 10 年来柬埔寨首例白喉棒状杆菌感染病例，突出表明了白喉诊断和报告的不足。提高临床医生的认识并在柬埔寨建立白喉监测非常重要。
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