Wen Xiang, Peng Jieqi, Zheng Youlan, Liu Jiaxing, Tian Heshen, Wu Fan, Wang Zihui, Yang Huajing, Deng Zhishan, Xiao Shan, Huang Peiyu, Xu Jianwu, Dai Cuiqiong, Zhao Ningning, Lu Lifei, Dai Jianwei, Li Bing, Ran Pixin, Zhou Yumin
National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University , Guangzhou Institutes of Biomedicine and Health Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China.
Chronic Obstr Pulm Dis. 2022 Jul 29;9(3):413-426. doi: 10.15326/jcopdf.2022.0310.
Eosinophils are involved in the development of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroid responsiveness. We evaluated clinical predictors of high sputum eosinophil levels in a COPD cohort in China.
We conducted an observational, prospective, population-based, cross-sectional study. Participants were tested for COPD and underwent spirometry, computed tomography scans, and a blood test. Participants also produced induced sputum and responded to an information-gathering questionnaire. High sputum eosinophils were defined as ≥3.0%. Multivariate logistic regression was used to identify predictors of high sputum eosinophil levels.
We recruited 895 patients with complete and quality control data. The median percentage of sputum eosinophil abundance was 2.00% (interquartile range: 0.75-5.00) and the prevalence of COPD with high sputum eosinophils was 38.0%. Covariance analysis indicated that the high sputum eosinophil group had lower lung function, more severe emphysema, and air trapping. Multivariate logistic regression indicated that high blood eosinophil levels, severe respiratory symptoms, being a former smoker, and a family history of respiratory diseases were associated with high sputum eosinophil levels.
High blood eosinophil levels, severe respiratory symptoms, being a former smoker, and a family history of respiratory diseases may be predictors of high sputum eosinophil levels in Chinese COPD patients. High sputum eosinophils were associated with lower lung function, more emphysema, and gas trapping.
嗜酸性粒细胞参与慢性阻塞性肺疾病（COPD）的发展及吸入性糖皮质激素反应性。我们评估了中国COPD队列中痰液嗜酸性粒细胞水平升高的临床预测因素。
我们进行了一项基于人群的观察性、前瞻性横断面研究。参与者接受了COPD检测，并进行了肺功能测定、计算机断层扫描和血液检测。参与者还留取了诱导痰并回答了一份信息收集问卷。痰液嗜酸性粒细胞水平高定义为≥3.0%。采用多因素逻辑回归分析来确定痰液嗜酸性粒细胞水平升高的预测因素。
我们招募了895例有完整且经过质量控制数据的患者。痰液嗜酸性粒细胞丰度的中位数百分比为2.00%（四分位间距：0.75 - 5.00），痰液嗜酸性粒细胞水平高的COPD患病率为38.0%。协方差分析表明，痰液嗜酸性粒细胞水平高的组肺功能较低、肺气肿更严重且存在气体潴留。多因素逻辑回归分析表明，血液嗜酸性粒细胞水平高、严重呼吸道症状、既往吸烟者以及呼吸道疾病家族史与痰液嗜酸性粒细胞水平高相关。
血液嗜酸性粒细胞水平高、严重呼吸道症状、既往吸烟者以及呼吸道疾病家族史可能是中国COPD患者痰液嗜酸性粒细胞水平高的预测因素。痰液嗜酸性粒细胞水平高与肺功能较低、肺气肿更严重及气体潴留相关。
