Jacobs School of Medicine & Biomedical Sciences.
Department of Pediatrics.
Curr Opin Rheumatol. 2022 Sep 1;34(5):262-266. doi: 10.1097/BOR.0000000000000893. Epub 2022 Jul 5.
To describe differences in disease manifestations and outcomes in pediatric rheumatic diseases as they occur in non-European-descended populations in North America.
Differences in disease prevalence, clinical phenotypes, disease course, and outcomes have been described across the spectrum of pediatric-onset rheumatic diseases. Although these differences are commonly explained by differences in genetic risk or access to tertiary healthcare facilities, our emerging understanding of the immunobiology of historical/ongoing trauma suggest a more complex explanation for these observed differences.
Health inequities as observed in pediatric rheumatic diseases are likely to emerge from a complex interplay between social and biological factors. The important contribution of historical and repetitive trauma deserves further exploration.
描述北美的非欧洲裔人群中儿童风湿性疾病的临床表现和结局的差异。
在儿童发病的风湿性疾病谱中,已经描述了疾病流行率、临床表型、疾病过程和结局的差异。尽管这些差异通常可以用遗传风险或获得三级医疗保健设施的差异来解释,但我们对历史/持续创伤的免疫生物学的认识不断加深,这为观察到的这些差异提供了一个更复杂的解释。
在儿科风湿性疾病中观察到的健康不平等现象可能是社会和生物因素复杂相互作用的结果。历史和反复创伤的重要贡献值得进一步探讨。