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慢性硬脑膜下血肿手术骨孔清除术与硬膜下引流系统的逆概率病例对照分析:临床和经济结局。

Inversed probability case-control analysis of operative burr hole evacuation versus subdural evacuating port system for chronic subdural hematomas: Clinical and economic outcomes.

机构信息

Department of Neurosurgery, College of Medicine, University of Florida, 1505 SW Archer Rd, Gainesville, FL 32601, USA.

Department of Neurosurgery, College of Medicine, University of Florida, 1505 SW Archer Rd, Gainesville, FL 32601, USA.

出版信息

Clin Neurol Neurosurg. 2022 Sep;220:107356. doi: 10.1016/j.clineuro.2022.107356. Epub 2022 Jul 2.

Abstract

INTRODUCTION

There are multiple treatments for a chronic subdural hematoma, a significant cause of neurosurgical morbidity that cost the healthcare system $5B in 2007, but few generalizable prospective studies. The purpose of this study was to examine outcomes of bedside Subdural Evacuation Port System (SEPS) placement as compared to operating room burr hole evacuation (BHE) to acquire data to support a randomized trial.

METHODS

All procedures were performed in a single institution between 2011 and 2019. Patients were included if > 18 years of age, had chronic subdural hematoma, and were treated by SEPS or BHE. Patients with prior neurosurgical history, mass lesions or bilateral hematomas were excluded. Patients who met inclusion for SEPS (n = 55) or BHE (n = 105). Samples were propensity matched to account for variability. Non-inferiority tests compared outcomes. Cost data was obtained through billable charges.

RESULTS

Patients with multiple comorbidities were more likely to undergo SEPS drainage. Noninferiority tests reported no statistically significant evidence to suggest SEPS drains were worse in reoperation-rate (18% vs 9%), post-operative seizure, or functional outcome. SEPS drain placement trended towards a faster time to procedure (3 h faster; p = 0.07) but the overall hospital stay was longer (4.23 vs 5.81, p = 0.01). SEPS drain placement costs are less than BHE, but these patients had 25% higher overall hospital costs (p = 0.01) due to comorbidities and increased hospital stay.

摘要

简介

慢性硬脑膜下血肿是神经外科发病率的一个重要原因,2007 年该病给医疗保健系统造成了 50 亿美元的损失,但针对这种疾病的前瞻性研究却很少。本研究的目的是比较床边硬脑膜下引流端口系统(SEPS)放置与手术室颅骨钻孔引流(BHE)的治疗效果,以获取支持随机试验的数据。

方法

所有手术均于 2011 年至 2019 年在一家机构进行。纳入标准为年龄大于 18 岁、患有慢性硬脑膜下血肿且接受 SEPS 或 BHE 治疗的患者。排除标准为有既往神经外科病史、肿块病变或双侧血肿的患者。符合 SEPS 纳入标准的患者(n=55)或 BHE 纳入标准的患者(n=105)。通过倾向评分匹配来调整样本,以消除变异性。非劣效性检验比较了治疗效果。通过计费收费获取成本数据。

结果

患有多种合并症的患者更有可能接受 SEPS 引流。非劣效性检验报告没有统计学证据表明 SEPS 引流在再次手术率(18% vs 9%)、术后癫痫或功能结局方面更差。SEPS 引流的手术时间更短(快 3 小时;p=0.07),但总住院时间更长(4.23 天 vs 5.81 天,p=0.01)。SEPS 引流的置管费用低于 BHE,但由于合并症和住院时间延长,这些患者的总住院费用增加了 25%(p=0.01)。

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