支气管肺发育不良和肺动脉高压的早期组织学变化可能先于早产儿的临床诊断。
Early histological changes of bronchopulmonary dysplasia and pulmonary hypertension may precede clinical diagnosis in preterm infants.
机构信息
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan, Hutzel Women's Hospital and Wayne State University School of Medicine, Detroit, MI, United States of America; Department of Pediatrics, Northwestern University, Chicago, IL, United States of America.
Division of Neonatal-Perinatal Medicine, Department of Pediatric Pathology, Children's Hospital of Michigan, Hutzel Women's Hospital and Wayne State University School of Medicine, Detroit, MI, United States of America.
出版信息
Early Hum Dev. 2022 Aug;171:105612. doi: 10.1016/j.earlhumdev.2022.105612. Epub 2022 Jun 23.
Bronchopulmonary Dysplasia (BPD), the commonest complication of prematurity, is defined by treatment with oxygen for ≥28 days. Pulmonary hypertension (PH) often coexists with BPD and is associated with increased mortality. In 42 autopsies, histological changes of BPD and PH were demonstrated in 25 % and 65 % respectively of preterm infants <28 days of age, highlighting the need for early diagnosis and treatment.
支气管肺发育不良（BPD）是早产儿最常见的并发症，其定义为需要接受氧气治疗≥28 天。肺动脉高压（PH）常与 BPD 并存，并与死亡率增加有关。在 42 例早产儿尸检中，分别有 25%和 65%的患儿在<28 天龄时出现 BPD 和 PH 的组织学改变，这突出表明需要早期诊断和治疗。
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