一种灭活传染性鼻炎疫苗佐剂的比较
Comparison of adjuvants for an inactivated infectious coryza vaccine.
作者信息
Reid G G, Blackall P J
出版信息
Avian Dis. 1987 Jan-Mar;31(1):59-63.
Differently formulated inactivated infectious coryza vaccines were administered to 6-week-old chickens as a single dose of 10(8) colony-forming units of Haemophilus paragallinarum HP31. After 3 weeks, all chickens were challenged by intrasinus inoculation of HP31. Two vaccines, one containing an aluminum-hydroxide adjuvant and the other a combined aluminum-hydroxide + mineral-oil adjuvant, gave the best protection (means of 80% and 90%, respectively). Two vaccines that contained mineral oil as the sole adjuvant gave less protection (50% and 35%). The Quil A vaccine gave no significant protection. Granulomatous swellings developed at the site of injection in birds given mineral-oil adjuvant but not in those that received other adjuvants.
将不同配方的灭活传染性鼻炎疫苗以10⁸个副鸡嗜血杆菌HP31菌落形成单位的单剂量给予6周龄的鸡。3周后，所有鸡通过鼻窦内接种HP31进行攻毒。两种疫苗，一种含有氢氧化铝佐剂，另一种含有氢氧化铝+矿物油复合佐剂，提供了最佳保护（分别为80%和90%的平均值）。两种仅含有矿物油作为佐剂的疫苗提供的保护较少（50%和35%）。Quil A疫苗没有提供显著保护。在给予矿物油佐剂的鸡的注射部位出现肉芽肿性肿胀，但在接受其他佐剂的鸡中未出现。
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