Paterson D J, Pinnington H, Pearce A R, Morton A R
Aviat Space Environ Med. 1987 Mar;58(3):243-7.
Three male and four female subjects were acutely exposed to normoxic and hypoxic gas mixtures (FIO2 = 17.39%, 14.40%, 11.81%) in a single-blind randomized fashion during four treadmill runs to volitional exhaustion. Maximal scores for oxygen consumption (VO2), carbon dioxide production and heart rate decreased linearly (p less than 0.01) with increasing hypoxia. Conversely, maximal scores for ventilation, ventilatory equivalent (VE/VO2) and R increased linearly (p less than 0.01) with decreasing FIO2. During hypoxia, no significant differences in work time or respiratory compensation threshold were evident. However, female subjects had significantly higher (p less than 0.05) VE/VO2 scores and showed a relative decrease in VO2max that was significantly less (p less than 0.01) than male subjects. It was concluded that young highly active females, when compared to males of similar age and relative condition, have a stronger adaptive response to acute hypoxia during a maximal treadmill run.
三名男性和四名女性受试者在四次跑步机跑步至自愿疲劳期间，以单盲随机方式急性暴露于常氧和低氧混合气体（FIO2 = 17.39%、14.40%、11.81%）中。随着低氧程度增加，耗氧量（VO2）、二氧化碳产生量和心率的最大值呈线性下降（p < 0.01）。相反，随着FIO2降低，通气量、通气当量（VE/VO2）和R的最大值呈线性增加（p < 0.01）。在低氧期间，工作时间或呼吸补偿阈值没有明显差异。然而，女性受试者的VE/VO2得分显著更高（p < 0.05），并且其最大摄氧量（VO2max）的相对下降幅度明显小于男性受试者（p < 0.01）。研究得出结论，与年龄和相对状况相似的男性相比，年轻且高活动水平的女性在最大跑步机跑步期间对急性低氧具有更强的适应性反应。
