Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran.
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
J Ethnopharmacol. 2022 Oct 28;297:115466. doi: 10.1016/j.jep.2022.115466. Epub 2022 Jul 4.
Cassia fistula is widely used in traditional Persian Medicine as a mild laxative. The rate of chronic constipation increases above the age of 60.
This study aimed to investigate the effect of Cassia fistula syrup (CFS) on geriatric constipation.
This clinical trial study was performed on 70 aged patients who were referred to the clinic of gastroenterology of Rouhani Hospital, Babol, North of Iran. Patients were randomly divided into two groups of CFS or Lactulose with a dose of 30 ccs/day. Patients were visited two weeks after entering the study to evaluate the frequency of defecation, feeling of incomplete emptying after defecation, manual maneuver, consistency of stool, and also the quality of life.
The frequency of defecation per week varied from 1.82 ± 1.16 to 8.36 ± 3.44 in the CFS group after 2 weeks of intervention that was significantly more than the Lactulose that changed from 2.16 ± 1.46 to 5.66 ± 2.96 (P-value = 0.023, partial eta square = 0.079, NNT = 4). The quality of life, the percent of straining, lumpy or hard stool, pain during defecation, and the consistency of stool based on VAS were significantly better in the CFS group. The sensation of incomplete defecation, anorectal obstruction, and manual maneuvering were not different significantly between groups.
CFS can be more effective than Lactulose on geriatric constipation.
木槿在传统波斯医学中被广泛用作温和的泻药。慢性便秘的发病率在 60 岁以上的人群中会增加。
本研究旨在探讨木槿糖浆（CFS）对老年便秘的疗效。
本临床试验研究对象为 70 名前往伊朗北部博尔巴卜鲁哈尼医院胃肠科就诊的老年患者。患者被随机分为 CFS 组或乳果糖组，剂量均为 30cc/天。患者在进入研究两周后接受访视，以评估排便频率、排便后不完全排空感、手动操作、粪便稠度以及生活质量。
干预 2 周后，CFS 组每周排便次数从 1.82±1.16 增加到 8.36±3.44，明显多于乳果糖组的 2.16±1.46 增加到 5.66±2.96（P 值=0.023，部分 eta 平方=0.079，NNH=4）。CFS 组的生活质量、用力排便的比例、块状或硬便、排便时疼痛以及基于 VAS 的粪便稠度均显著改善。CFS 组在不完全排便感、肛门直肠梗阻和手动操作方面与乳果糖组无显著差异。
CFS 对老年便秘的疗效可能优于乳果糖。
