Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, United Kingdom; MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, United Kingdom.
Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, United Kingdom; Department of Psychology (Scarborough), University of Toronto, Toronto, ON, Canada.
Prog Neurobiol. 2022 Oct;217:102314. doi: 10.1016/j.pneurobio.2022.102314. Epub 2022 Jul 4.
Primate frontopolar cortex (FPC), occupied by area 10, sits atop a functional hierarchy of prefrontal cortical regions, yet little is known about its involvement in wider cortical networks. Here we examined resting-state-functional-connectivity (rsfc) in rhesus monkeys with intact or lesioned FPC to identify cortical regions associated with FPC. We present a network of FPC-specific regions of interest (ROIs), whose connectivity was affected by lesion of FPC but not by lesion of neighbouring prefrontal cortex (principal sulcus). This network comprised 'core ROIs' with direct anatomical connections to FPC, located in ventrolateral prefrontal cortex, posterior cingulate cortex, and superior temporal gyrus, and 'peripheral ROIs' well connected to the core network. We further show that the principle effect of a lesion to FPC was to cause a profound disturbance of the functional connectivity of posterior cingulate and ventrolateral prefrontal cortex. We therefore suggest that FPC, posterior cingulate and ventrolateral prefrontal cortex comprise a network of interacting cortical areas whose interactions may be critical for mediating the contribution of FPC to decision making.
灵长类动物额极皮质（FPC），由 10 区占据，位于前额皮质区域的功能层次结构之上，但人们对其在更广泛的皮质网络中的作用知之甚少。在这里，我们通过检查具有完整或受损 FPC 的恒河猴的静息状态功能连接（rsfc），以确定与 FPC 相关的皮质区域。我们提出了一个 FPC 特异性感兴趣区域（ROI）的网络，其连接性受到 FPC 损伤的影响，但不受相邻前额叶皮质（主沟）损伤的影响。该网络包括与 FPC 有直接解剖连接的“核心 ROI”，位于腹外侧前额皮质、后扣带回和颞上回，以及与核心网络连接良好的“外围 ROI”。我们进一步表明，FPC 损伤的主要影响是导致后扣带回和腹外侧前额皮质的功能连接发生深刻紊乱。因此，我们建议 FPC、后扣带回和腹外侧前额皮质构成了一个相互作用的皮质区域网络，它们的相互作用可能对介导 FPC 对决策的贡献至关重要。
