Todo G, Herman P G
Invest Radiol. 1986 Sep;21(9):689-96. doi: 10.1097/00004424-198609000-00003.
Computed tomographic (CT)-anatomic correlation of the lung was performed on young Yorkshire pigs. After in vivo CT, the lungs were removed, fixed, and dried. The lung specimens were studied with CT and on several specimens, bronchography and arteriography also were done to establish the normal anatomy. Subsequently, the specimens were sliced at corresponding levels of the CT cuts and histology was done as needed. The lobules in the pig lung are very well demarcated. On the specimen radiographs with bronchography and in vivo CT in pulmonary edema, "sublobular units" can be readily identified that are rather uniform in size. On the in vivo CT with the standard algorithm, the relationship between the branches of the pulmonary artery and bronchus can be shown to the level of segmental bronchi. With the bone detail algorithm, vessels are clearly shown and lobar bronchi become visible. On in vivo CT, the lobular demarcations cannot be seen in the normal pig but clearly are visible in pulmonary edema. In cases of pulmonary edema, in addition to the lobules, the sublobular units and the sublobular bronchi, which measure .5 to .7 mm in diameter, also can be appreciated. Because of the well-developed pulmonary lobules and the uniformly sized sublobular units, the Yorkshire pig is potentially a good model for radiologic-pathologic correlation, particularly of airspace disease.
对幼年约克夏猪进行了肺部计算机断层扫描（CT）与解剖结构的相关性研究。在进行体内CT扫描后，取出肺部，进行固定和干燥处理。对肺标本进行CT研究，对部分标本还进行了支气管造影和动脉造影以确定正常解剖结构。随后，将标本在与CT扫描相应的层面进行切片，并根据需要进行组织学检查。猪肺中的小叶界限非常清晰。在伴有支气管造影的标本X线片以及肺水肿的体内CT图像上，可以很容易地识别出大小相当均匀的“小叶下单位”。在采用标准算法的体内CT图像上，肺动脉和支气管分支之间的关系可显示至段支气管水平。采用骨细节算法时，血管清晰可见，叶支气管也变得可见。在体内CT图像上，正常猪的小叶界限不可见，但在肺水肿时则清晰可见。在肺水肿病例中，除了小叶外，直径为0.5至0.7毫米的小叶下单位和小叶下支气管也可以辨认出来。由于猪肺小叶发育良好且小叶下单位大小均匀，约克夏猪有可能成为影像学与病理学相关性研究的良好模型，尤其是对气腔疾病的研究。
