预防胰腺癌常用药物的最新进展
An Update on Common Pharmaceuticals in the Prevention of Pancreatic Cancer.
作者信息
Miyaki Candace, Lynch Launa M
机构信息
Internal Medicine, Idaho College of Osteopathic Medicine, Meridian, USA.
Pharmacology, Idaho College of Osteopathic Medicine, Meridian, USA.
出版信息
Cureus. 2022 May 30;14(5):e25496. doi: 10.7759/cureus.25496. eCollection 2022 May.
Abstract
In this review, we aim to update readers about the most recent studies on common pharmaceuticals and their association with pancreatic cancer risk. The use of prophylactic aspirin, metformin, beta-blockers, and statins has been studied in the past but showed inconclusive results in the reduction of pancreatic cancer incidence. However, in recent studies, these medications along with combination therapy of aspirin and metformin were found to have a more significant association with decreasing risk. Given the poor prognosis of pancreatic cancer despite treatment, medication prophylaxis prevention should be considered. In this review, we hope to encourage future case-control or prospective studies on common medications that have shown great potential in delaying pancreatic cancer development.
摘要
在本综述中，我们旨在向读者介绍有关常见药物及其与胰腺癌风险关联的最新研究。过去曾对预防性使用阿司匹林、二甲双胍、β受体阻滞剂和他汀类药物进行过研究，但在降低胰腺癌发病率方面结果尚无定论。然而，在最近的研究中，发现这些药物以及阿司匹林和二甲双胍的联合疗法与降低风险的关联更为显著。鉴于胰腺癌即使经过治疗预后仍较差，应考虑进行药物预防。在本综述中，我们希望鼓励未来针对在延缓胰腺癌发展方面显示出巨大潜力的常见药物开展病例对照或前瞻性研究。
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