中国高血压患者的变异与肾功能
Variation and Renal Function in Chinese Patients With Hypertension.
作者信息
Huang Chin-Chou, Chung Chia-Min, Yang Chih-Yu, Leu Hsin-Bang, Huang Po-Hsun, Lin Liang-Yu, Wu Tao-Cheng, Lin Shing-Jong, Pan Wen-Harn, Chen Jaw-Wen
机构信息
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
出版信息
Front Med (Lausanne). 2022 Jun 21;9:863275. doi: 10.3389/fmed.2022.863275. eCollection 2022.
OBJECTIVE
(solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown. We aimed to investigate the association between gene polymorphisms and renal function in patients with hypertension.
METHODS
Participants from three non-diabetic hypertensive cohorts, including young-onset hypertension (cohort 1, = 882), treatment-naïve hypertension (cohort 2, = 90), and follow-up cohort (cohort 3, = 166), underwent genotyping for single nucleotide polymorphisms in . Renal events were defined as a >25 and >50% decline in estimated glomerular filtration rate (eGFR).
RESULTS
In cohort 1, rs16963397 C/C or C/G ( = 0.005), rs13334864 C/C or C/T ( = 0.020), and rs7187932 A/A or A/G polymorphisms ( = 0.014) had higher eGFRs compared to their counterparts, with similar findings observed in cohort 2. In cohort 3, over a mean follow-up of 5.8 ± 1.7 years, participants with either rs16963397 C/C or rs13334864 C/C polymorphisms had more >25 and >50% eGFR decline than their counterparts (log-rank test, = 0.058 and = 0.038, respectively). Cox regression analysis revealed that rs16963397 C/C and rs13334864 C/C polymorphisms were significantly associated with an increased risk of >25% [hazard ratio (HR), 3.294; 95% confidence interval (CI), 1.158-9.368; = 0.025] and >50% decline in eGFR (HR, 18.630; 95% CI, 1.529-227.005, = 0.022) than their counterparts.
CONCLUSION
polymorphisms are associated with renal function in Chinese patients with hypertension.
目的
溶质载体家族12成员3（SLC12A3）基因变异与糖尿病肾病相关；然而，其与高血压肾病的关联尚不清楚。我们旨在研究SLC12A3基因多态性与高血压患者肾功能之间的关联。
方法
来自三个非糖尿病高血压队列的参与者，包括青年发病型高血压（队列1，n = 882）、未经治疗的高血压（队列2，n = 90）和随访队列（队列3，n = 166），接受了SLC12A3单核苷酸多态性的基因分型。肾脏事件定义为估计肾小球滤过率（eGFR）下降>25%和>50%。
结果
在队列1中，SLC12A3基因rs16963397位点C/C或C/G基因型（P = 0.005）、rs13334864位点C/C或C/T基因型（P = 0.020）以及rs7187932位点A/A或A/G多态性（P = 0.014）的eGFR高于其他基因型，队列2中也观察到类似结果。在队列3中，平均随访5.8±1.7年，rs16963397位点C/C或rs13334864位点C/C多态性的参与者eGFR下降>25%和>50%的比例高于其他参与者（对数秩检验，P分别为0.058和0.038）。Cox回归分析显示，rs16963397位点C/C和rs13334864位点C/C多态性与eGFR下降>25%[风险比（HR），3.294；95%置信区间（CI），1.158 - 9.368；P = 0.025]和>50%的风险增加显著相关（HR，18.630；95%CI，1.529 - 227.005，P = 0.022）。
结论
SLC12A3基因多态性与中国高血压患者的肾功能相关。
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