硫代酰胺导向的铱（I）催化二茂铁与芳基硼酸的 C-H 芳基化反应。
Thioamide directed iridium(I)-catalyzed C-H arylation of ferrocenes with aryl boronic acids.
机构信息
School of Chemistry and Chemical Engineering, Ningxia University, 489 Helanshan West Road, Yinchuan 750021, People's Republic of China.
State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, PR China.
出版信息
Org Biomol Chem. 2022 Jul 27;20(29):5759-5763. doi: 10.1039/d2ob00863g.
The first Ir(I)-catalyzed thioamide-assisted C-H arylation of ferrocenes with aryl boronic acids under base-free mild reaction conditions in the presence of AgCO as an oxidant with eco-friendly 2-MeTHF as a solvent was developed. This reaction has a wide range of substrates (37 examples) and functional group tolerance (18-94% yields), and provides promising access to aryl thioamide-ferrocene compounds with good yields and regioselectivity.
发展了一种在无碱温和反应条件下，以 AgCO3 为氧化剂、环保的 2-MeTHF 为溶剂，在第一例 Ir(I)-催化下、硫代酰胺辅助的二茂铁与芳基硼酸的 C-H 芳基化反应。该反应具有广泛的底物适用性（37 个例子）和官能团容忍性（产率 18-94%），为高产率和区域选择性地获得芳基硫代酰胺-二茂铁化合物提供了有前景的途径。
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