Department of Neurology, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland.
Department of Neurosurgery, Bródno Regional Hospital, Warsaw, Poland.
Pol Merkur Lekarski. 2022 Jun 24;50(297):177-182.
Ischemic stroke is the main cause of permanent disability in adult patients. No commonly accepted method were discovered to predict stroke before the first symptoms. Activation of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMP) and S100B protein may be observe in patients with symptomatic carotid artery stenosis. Hemorrhagic transformation of ischemic stroke may be associated with changes in MMP, TIMP and S100B.
The aim of this study was to determine if MMP-9, TIMP-1 and S-100B protein may markers of forthcoming ischemic stroke in patients undergoing carotid endarterectomy.
Blood samples were taken and an analysis of circulating proteins (MMP-9, TIMP-1, S100B) 73 subsequent patients with carotid artery stenosis ≥70% (33 asymptomatic and 40 symptomatic), who were referred for potential revascularization.
A statistically significant difference was found between MMP- 9 levels in patients with ischemic stroke compared to patients with asymptomatic carotid stenosis after endarterectomy. Also, average TIMP-1 levels in patients with ischemic stroke and stenosis ≥70% were statistically significantly higher than the average levels in patients after endarterectomy. In terms of S-100B, a higher mean value was observed in patients with stroke than in endarterectomy group. No statistical differences were found in the levels of that proteins in the hemorrhagic transformation of ischemic stroke.
Increased levels of MMP-9, TIMP-1 and S-100B in patients with ischemic stroke compared to patients with asymptomatic carotid stenosis after endarterectomy showed that abovementioned proteins may be a good predictive factor of ischemic stroke in patients undergoing carotid endarterectomy.
本研究旨在确定 MMP-9、TIMP-1 和 S100B 蛋白是否可作为颈动脉内膜切除术患者即将发生缺血性卒中的标志物。
对 73 例颈动脉狭窄≥70%（33 例无症状和 40 例有症状）的患者进行血液样本采集和循环蛋白（MMP-9、TIMP-1、S100B）分析，这些患者被推荐进行潜在的血运重建。
与颈动脉内膜切除术后无症状颈动脉狭窄患者相比，缺血性卒中患者的 MMP-9 水平存在统计学显著差异。此外，缺血性卒中且狭窄≥70%的患者的平均 TIMP-1 水平明显高于颈动脉内膜切除术后患者的平均水平。就 S-100B 而言，卒中患者的平均数值高于内膜切除术组。在缺血性卒中的出血性转化中，这些蛋白质的水平没有统计学差异。
与颈动脉内膜切除术后无症状颈动脉狭窄患者相比，缺血性卒中患者的 MMP-9、TIMP-1 和 S-100B 水平升高表明，上述蛋白可能是颈动脉内膜切除术患者缺血性卒中的良好预测因子。
