Department of Nuclear Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, China.
Prion. 2022 Dec;16(1):91-94. doi: 10.1080/19336896.2022.2093078.
Creutzfeldt-Jakob disease (CJD) is a low-prevalence, fatal neurodegenerative disease. Parkinsonism as first symptom of CJD is rare. We present a case manifesting difficulty falling asleep as unspecific prodromal symptom and parkinsonism as initial symptom. The patient received positron emission tomography/computed tomography (PET/CT) of dopamine transporter (DAT) using 18 F-FP-CIT. The DAT-scan demonstrated presynaptic dopaminergic deficit in bilateral posterior putamen, which supports the hypothesis of nigrostriatal pathway dysfunction in CJD.
克雅氏病（CJD）是一种低发病率、致命的神经退行性疾病。帕金森病作为 CJD 的首发症状较为罕见。我们报告了一例以入睡困难为非特异性前驱症状和帕金森病为首发症状的病例。患者接受了使用 18F-FP-CIT 的正电子发射断层扫描/计算机断层扫描（PET/CT）的多巴胺转运蛋白（DAT）检查。DAT 扫描显示双侧后壳核存在多巴胺能前突触缺陷，这支持了 CJD 中黑质纹状体通路功能障碍的假说。
